Anti-BCMA antibodies and uses thereof
First Claim
1. A recombinant antibody, or an antigen-binding fragment thereof, that binds immunospecifically to BCMA, wherein the antibody has a heavy chain and a light chain, said heavy chain and light chain comprising:
- a heavy chain complementarity determining region 1 (CDR1) having the amino acid sequence of SEQ ID NO;
4, a heavy chain CDR2 having the amino acid sequence of SEQ ID NO;
5, and a heavy chain CDR3 having the amino acid sequence of SEQ ID NO;
6, a light chain CDR1 having the amino acid sequence of SEQ ID NO;
24, a light chain CDR2 having the amino acid sequence of SEQ ID NO;
25, and a light chain CDR3 having the amino acid sequence of SEQ ID NO;
26.
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Accused Products
Abstract
Provided herein are antibodies that immunospecifically bind to BCMA. Also described are related polynucleotides capable of encoding the provided BCMA-specific antibodies or antigen-binding fragments, cells expressing the provided antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled antibodies or antigen-binding fragments. In addition, methods of using the provided antibodies are described. For example, the provided antibodies may be used to diagnose, treat, or monitor BCMA-expressing cancer progression, regression, or stability; to determine whether or not a patient should be treated for cancer; or to determine whether or not a subject is afflicted with BCMA-expressing cancer and thus may be amenable to treatment with a BCMA-specific anti-cancer therapeutic, such as the multispecific antibodies against BCMA and CD3 described herein.
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Citations
16 Claims
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1. A recombinant antibody, or an antigen-binding fragment thereof, that binds immunospecifically to BCMA, wherein the antibody has a heavy chain and a light chain, said heavy chain and light chain comprising:
a heavy chain complementarity determining region 1 (CDR1) having the amino acid sequence of SEQ ID NO;
4, a heavy chain CDR2 having the amino acid sequence of SEQ ID NO;
5, and a heavy chain CDR3 having the amino acid sequence of SEQ ID NO;
6, a light chain CDR1 having the amino acid sequence of SEQ ID NO;
24, a light chain CDR2 having the amino acid sequence of SEQ ID NO;
25, and a light chain CDR3 having the amino acid sequence of SEQ ID NO;
26.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
Specification