System for operating a system for the integrated and automated analysis of DNA or protein
First Claim
1. A system for the integrated an automated analysis of DNA or protein, comprising:
- a cartridge to receive a sample to be analyzed, the cartridge containing a reagent for analysis of the sample;
a control device for controlling an analysis process, wherein the control device comprises;
a cartridge receptacle for receiving the cartridge;
means for moving a part of the cartridge receptacle upon insertion of the cartridge into the cartridge receptacle, such that the cartridge is correctly received in the cartridge receptacle;
a microcontroller for control and data acquisition; and
wherein the two parts of the cartridge receptacle are brought together as soon as the cartridge has been completely introduced in the cartridge receptacle,wherein the control device comprises a thermostatic regulation device for carrying out at least one thermocycling process, wherein the thermostatic regulation device comprises two thermal coupling plates arranged so as to provide good thermal contact with the cartridge while avoiding thermal contact between the thermal coupling plates and the cartridge receptacle, and wherein the cartridge, in an inserted state, is situated between the thermal coupling plates and the thermal coupling plates are pressed against the cartridge such that the cartridge is held between the thermal coupling plates.
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Accused Products
Abstract
A system for the integrated and automated analysis of DNA or protein, including a single-use cartridge, with an analysis device having a control device, and devices for capturing and processing signals, the control device carrying out a completely automatic process and evaluation of molecular diagnostic analysis via single-use cartridges (Lab-on-a-Chip). Controlling of an analysis process, which occurs in the cartridge, involves the subsequent displacement and thermostatization of liquids with a first device, and with a second device the signals which are obtained during the analysis are processed. The first and the second devices are synchronized in such a manner that the analysis process of the sample can be carried out in a totally integrated manner thus producing an immediate result.
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Citations
38 Claims
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1. A system for the integrated an automated analysis of DNA or protein, comprising:
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a cartridge to receive a sample to be analyzed, the cartridge containing a reagent for analysis of the sample; a control device for controlling an analysis process, wherein the control device comprises; a cartridge receptacle for receiving the cartridge; means for moving a part of the cartridge receptacle upon insertion of the cartridge into the cartridge receptacle, such that the cartridge is correctly received in the cartridge receptacle; a microcontroller for control and data acquisition; and wherein the two parts of the cartridge receptacle are brought together as soon as the cartridge has been completely introduced in the cartridge receptacle, wherein the control device comprises a thermostatic regulation device for carrying out at least one thermocycling process, wherein the thermostatic regulation device comprises two thermal coupling plates arranged so as to provide good thermal contact with the cartridge while avoiding thermal contact between the thermal coupling plates and the cartridge receptacle, and wherein the cartridge, in an inserted state, is situated between the thermal coupling plates and the thermal coupling plates are pressed against the cartridge such that the cartridge is held between the thermal coupling plates. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A system for the integrated and automated analysis of DNA or protein, comprising:
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a cartridge to receive a sample to be analyzed, the cartridge containing a reagent for analysis of the sample; a control device for controlling an analysis process, wherein the control device comprises; a cartridge receptacle for receiving the cartridge with two parts; a microcontroller for control and data acquisition; and a chip module for detection of DNA or protein; wherein as soon as the cartridge has been completely introduced the two parts are brought together and the cartridge is locked or clamped inbetween, wherein the chip module is thermally coupled to a Peltier element, wherein the Peltier element is connected to one of the parts of the cartridge receptacle, and wherein the Peltier element and chip are biased against each other in a resilient fashion. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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Specification