Systems and methods for visualizing ablated tissue
First Claim
Patent Images
1. A system for imaging tissue comprising:
- an endovascular catheter having a distal end and a proximal end;
an ablation device disposed at the distal end of the endovascular catheter for ablating the tissue;
an inflatable balloon disposed about the distal end of the catheter;
an optical housing extending from the catheter into the balloon, the optical housing comprising a light source providing light between about 300 nm and about 400 nm for illuminating a tissue outside the balloon to excite mitochondrial nicotinamide adenine dinucleotide hydrogen (NADH) in the tissue and a sensor being configured to receive light between about 435 nm and about 485 nm to detect NADH fluorescence from the illuminated tissue; and
a processor associated with the sensor and configured to generate a digital representation of the illuminated tissue to distinguish between ablated tissue and non-ablated tissue;
wherein the light source and the sensor are positioned inside the balloon.
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Abstract
Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.
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Citations
14 Claims
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1. A system for imaging tissue comprising:
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an endovascular catheter having a distal end and a proximal end; an ablation device disposed at the distal end of the endovascular catheter for ablating the tissue; an inflatable balloon disposed about the distal end of the catheter; an optical housing extending from the catheter into the balloon, the optical housing comprising a light source providing light between about 300 nm and about 400 nm for illuminating a tissue outside the balloon to excite mitochondrial nicotinamide adenine dinucleotide hydrogen (NADH) in the tissue and a sensor being configured to receive light between about 435 nm and about 485 nm to detect NADH fluorescence from the illuminated tissue; and a processor associated with the sensor and configured to generate a digital representation of the illuminated tissue to distinguish between ablated tissue and non-ablated tissue; wherein the light source and the sensor are positioned inside the balloon. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A system for imaging tissue comprising:
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an endovascular catheter having a distal end and a proximal end; an ablation device disposed at the distal end of the endovascular catheter for ablating a tissue; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon; a light source disposed inside the balloon, the light source being supported by the optical housing and configured to provide light between about 300 nm and about 400 nm to excite NADH in a tissue; a sensor disposed inside the balloon, the sensor being supported by the optical housing and configured to detect NADH fluorescence from the tissue illuminated by the light source; and a processor associated with the sensor and configured to generate a digital representation of the illuminated tissue to distinguish between ablated tissue and non-ablated tissue. - View Dependent Claims (9)
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10. A method for imaging tissue comprising:
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advancing to a tissue an endovascular catheter comprising an inflatable balloon disposed about the distal end of the catheter and an optical housing extending into the balloon to position a light source and a sensor inside the balloon, wherein the light source and the sensor are supported by the optical housing and are positioned inside the balloon; ablating the tissue with an ablation device disposed at the distal end of the endovascular catheter; illuminating with light between about 300 nm and about 400 nm from the light source an area of tissue including tissue treated by ablation and surrounding tissue to excite NADH in the area of tissue; detecting with the sensor the area of tissue to detect light between about 435 nm and about 485 nm to detect NADH fluorescence of the area of tissue; and producing a representation of the illuminated tissue, the display illustrating ablated tissue as having less fluorescence than non-ablated tissue. - View Dependent Claims (11, 12, 13)
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14. A system for imaging tissue comprising:
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an endovascular catheter having a distal end and a proximal end; an ablation device disposed at the distal end of the endovascular catheter for ablating the tissue; a light source providing light between about 300 nm and about 400 nm for illuminating a tissue to excite mitochondrial nicotinamide adenine dinucleotide hydrogen (NADH) in the tissue; a sensor for detecting NADH fluorescence from the illuminated tissue, the sensor being configured to receive light between about 435 nm and about 485 nm to detect the NADH fluorescence from the illuminated tissue; one or more optical fibers to deliver the light from the light source to the tissue and to deliver the NADH fluorescence to the sensor; and a processor associated with the sensor and configured to generate a digital representation of the illuminated tissue to distinguish between ablated tissue and non-ablated tissue.
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Specification