Real-time monitoring and control of physical and arousal status of individual organisms
First Claim
1. A method of monitoring an estimation of an arousal component of a heart rate (HRPhAr) of an individual human or animal on the basis of a model capable of integrating measured, real-time information on one or more bioprocess inputs and one or more bioprocess outputs and linking the information to the estimation of the arousal component of the heart rate of the individual human or animal (HRPhAr), the heart rate having a physical component (HRphys) and the arousal component (HRPhAr), the method being executed in a computer under the control of a program stored in the computer and comprising:
- using at least one sensor for measuring real-time information on bioprocess inputs and/or bioprocess outputs,generating the model on-line,inputting, to the model, the real-time information on bioprocesses of the human or animal,generating, responsive to the input real-time information, model outputs using a dynamic and adaptive data-based on-line modelling technique, wherein at least one of the bioprocess inputs or outputs used as model input is a metabolism-related variable relating to the metabolic energy and/or mobilized energy of the human or animal, which is a measurable factor affecting the bioprocess, and at least one of the model outputs is an estimated component of the heart rate (HRmech) based on at least the one metabolism-related variable relating to the metabolic energy and/or mobilized energy, and wherein the model is updated on-line by adapting parameters of the model in real-time based on estimating and predicting the model outputs and comparing the model outputs in real-time with measured bioprocess outputs,measuring in real-time the measured heart rate of the individual human or animal (HRtot),outputting information about the measured heart rate (HRtot) to an output component, andusing the information about the heart rate (HRtot) to control said physical component (HRphys) or said arousal component (HRPhAr), by adapting at least one of the bioprocess inputs and/or an environmental variable changing a relationship between the bioprocess input and the bioprocess output,determining a value for an unknown variable attributed to the estimation of the arousal component (HRPhAr) from a set of equations, wherein at least the heart rate (HRtot) and the estimated component of the heart rate (HRmech) are known variables, andusing the value of the unknown variable to monitor and/or control the arousal component of the heart rate (HRPhAr),wherein a component of the heart rate relating to basal metabolism (HRbmr) and a component of the heart rate relating to heat balance (HRheat) are additional known variables in the set of equations,wherein the estimation of the arousal component (HRPhAr) is determined by subtracting in real-time (a) the component of the heart rate relating to basal metabolism (HRbmr) and the component of the heart rate relating to heat balance (HRheat) from (b) the difference between the real-time measured heart rate (HRtot) and a mechanical activity component, the mechanical activity component being the estimated component of the heart rate (HRmech),wherein the resulting difference between (b) and (a) is the value of the unknown variable attributed to the estimation of the arousal component (HRPhAr),wherein generating the model on-line includes expressing the real-time measured heart rate as
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Abstract
The present invention relates to methods and systems for monitoring and controlling the status of humans or animals, in particular relating to both the physical and the arousal status of an individual human or animal. These methods and systems rely on a dynamic and adaptive data-based on-line modelling technique wherein information on bioprocess inputs and outputs is measured in real-time and the model predicts an output based on the bioprocess input. The provided methods are particularly useful to monitor and/or control processes in which performance is important.
18 Citations
34 Claims
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1. A method of monitoring an estimation of an arousal component of a heart rate (HRPhAr) of an individual human or animal on the basis of a model capable of integrating measured, real-time information on one or more bioprocess inputs and one or more bioprocess outputs and linking the information to the estimation of the arousal component of the heart rate of the individual human or animal (HRPhAr), the heart rate having a physical component (HRphys) and the arousal component (HRPhAr), the method being executed in a computer under the control of a program stored in the computer and comprising:
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using at least one sensor for measuring real-time information on bioprocess inputs and/or bioprocess outputs, generating the model on-line, inputting, to the model, the real-time information on bioprocesses of the human or animal, generating, responsive to the input real-time information, model outputs using a dynamic and adaptive data-based on-line modelling technique, wherein at least one of the bioprocess inputs or outputs used as model input is a metabolism-related variable relating to the metabolic energy and/or mobilized energy of the human or animal, which is a measurable factor affecting the bioprocess, and at least one of the model outputs is an estimated component of the heart rate (HRmech) based on at least the one metabolism-related variable relating to the metabolic energy and/or mobilized energy, and wherein the model is updated on-line by adapting parameters of the model in real-time based on estimating and predicting the model outputs and comparing the model outputs in real-time with measured bioprocess outputs, measuring in real-time the measured heart rate of the individual human or animal (HRtot), outputting information about the measured heart rate (HRtot) to an output component, and using the information about the heart rate (HRtot) to control said physical component (HRphys) or said arousal component (HRPhAr), by adapting at least one of the bioprocess inputs and/or an environmental variable changing a relationship between the bioprocess input and the bioprocess output, determining a value for an unknown variable attributed to the estimation of the arousal component (HRPhAr) from a set of equations, wherein at least the heart rate (HRtot) and the estimated component of the heart rate (HRmech) are known variables, and using the value of the unknown variable to monitor and/or control the arousal component of the heart rate (HRPhAr), wherein a component of the heart rate relating to basal metabolism (HRbmr) and a component of the heart rate relating to heat balance (HRheat) are additional known variables in the set of equations, wherein the estimation of the arousal component (HRPhAr) is determined by subtracting in real-time (a) the component of the heart rate relating to basal metabolism (HRbmr) and the component of the heart rate relating to heat balance (HRheat) from (b) the difference between the real-time measured heart rate (HRtot) and a mechanical activity component, the mechanical activity component being the estimated component of the heart rate (HRmech), wherein the resulting difference between (b) and (a) is the value of the unknown variable attributed to the estimation of the arousal component (HRPhAr), wherein generating the model on-line includes expressing the real-time measured heart rate as - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A system for monitoring an estimation of an arousal component of a heart rate of an active individual human or animal (HRPhAr), the heart rate (HRtot) having a physical (HRphys) and the arousal component (HRPhAr), comprising
(a) at least one sensor for measuring real-time information regarding bioprocess inputs and bioprocess outputs, wherein at least one of the bioprocess inputs or outputs is a variable relating to the metabolic energy and/or mobilized energy of the human or animal, which is a measurable factor affecting the bioprocess; -
(b) measured real-time information; (c) a first processor connected to communicate with the first device for on-line modelling and generating an estimated component of the heart rate of the human or animal (HRmech), based on at least the variable relating to the metabolic energy and/or mobilized energy, said first processor further configured and operable to on-line adapt model parameters in real-time, based on estimating and predicting model outputs and comparing the predicted model outputs in real-time with the measured bioprocess outputs; and an output component operably coupled to the first device, that prompts a change in a status of the human or animal by adapting at least one of the bioprocess inputs and/or an environmental variable changing a relationship between the bioprocess input and the bioprocess output, wherein the estimation of the arousal component (HRPhAh) is determined by subtracting (i) a component of the heart rate relating to basal metabolism (HRbmr) and a component of the heart rate relating to heat balance (HRheat) from (ii) the difference between the heart rate (HRtot) and a mechanical activity component, the mechanical activity component being the estimated component of the heart rate (HRmech), wherein the resulting difference between (ii) and (i) is the estimation of the arousal component (HRPhAr), wherein the first device and the first processor are adapted to use a model in which the real-time measured heart rate (HRtot) is expressed as - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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34. A computer program product, tangibly embodied in a non-transitory machine-readable medium for execution by a processor, the computer program product being operable to cause data processing for use in a system for monitoring an estimation of an arousal component of heart rate of an individual human or animal, the heart rate (HRtot) having a physical component (HRphys) and the arousal component (HRPhAr),
the computer program comprising software code which when executed on a processing engine having a processor and memory provides: -
(a) software code for collecting and storing real-time information on bioprocess inputs and outputs, wherein at least one of the bioprocess inputs is a variable relating to the metabolic energy and/or mobilized energy of the human or animal, which is a measurable factor affecting the bioprocess; and (b) software code for on-line modelling and generating an estimation of a component of the heart rate of the human or animal (HRmech), based on the variable relating to the metabolic energy and/or mobilized energy, the computer program product being adapted to estimate the arousal component (HRPhAr) by subtracting the estimated component of the heart rate (HRmech), the component of the heart rate relating to basal metabolism (HRbmr) and the component of the heart rate relating to heat balance (HRheat) from the measured heart rate (HRtot) and the resulting difference is a value of an unknown variable attributed to the arousal component of the heart rate (HRPhAr) wherein the computer program further comprises a model in which the real-time measured heart rate (HRtot) is expressed as
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Specification