Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage
First Claim
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1. An apparatus for treating damaged cardiac tissue, comprising:
- a porous bio-incorporable material for treating damaged cardiac tissue having a pore structure configured to permit gaseous communication between one or more pores of the porous material and the cardiac tissue to be treated;
a cover for placement over the damaged cardiac tissue and porous bio-incorporable material for maintaining sub-atmospheric pressure at the damaged cardiac tissue, wherein the cover comprises a bio-incorporable material; and
a vacuum source for producing sub-atmospheric pressure disposed in gaseous communication with the porous material for distributing the sub-atmospheric pressure to the cardiac tissue to be treated,wherein the rate of bio-incorporation of the porous material is higher at the periphery of the porous material than at the center of the porous material.
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Abstract
A method and apparatus are provided for treating cardiac tissue to modulate ischemic heart tissue with topical sub-atmospheric pressure to minimize cell death and damage.
491 Citations
45 Claims
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1. An apparatus for treating damaged cardiac tissue, comprising:
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a porous bio-incorporable material for treating damaged cardiac tissue having a pore structure configured to permit gaseous communication between one or more pores of the porous material and the cardiac tissue to be treated; a cover for placement over the damaged cardiac tissue and porous bio-incorporable material for maintaining sub-atmospheric pressure at the damaged cardiac tissue, wherein the cover comprises a bio-incorporable material; and a vacuum source for producing sub-atmospheric pressure disposed in gaseous communication with the porous material for distributing the sub-atmospheric pressure to the cardiac tissue to be treated, wherein the rate of bio-incorporation of the porous material is higher at the periphery of the porous material than at the center of the porous material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 43, 44)
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32. A degradable or resorbable vacuum appliance for treating injured or diseased tissues in a body, comprising:
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a dressing configured to be implanted in the body, the dressing having a void structure configured to permit the transmission of sub-atmospheric pressure therethrough; and a bio-incorporable cover configured to be implanted in the body to cover and enclose the dressing to provide a chamber about the dressing in which sub-atmospheric pressure may be maintained, wherein the rate of bio-incorporation of the dressing is higher at the periphery of the dressing than at the center of the dressing. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 45)
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Specification