Polymers, preparation and use thereof

• US 10,077,324 B2
• Filed: 01/14/2014
• Issued: 09/18/2018
• Est. Priority Date: 02/06/2013
• Status: Active Grant

• Current Assignee: Solventum Intellectual Properties Company (Solventum Corp.)
• Original Assignee: KCI Licensing Incorporated (3M Company)
• Inventors: Vail, Neal
• Primary Examiner(s): Cai, Wenwen
• Application Number:
  US14/766,191
• Publication Number:
  US 20160108144A1
• Time in Patent Office: 1,708 Days
• Field of Search: 526286
• CPC Class Codes: A61L 24/0015 Medicaments; Biocides
• CPC Class Codes: A61L 24/043 Mixtures of macromolecular materials
• CPC Class Codes: C08F 28/02 by a bond to sulfur
• CPC Class Codes: C08G 83/00 Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00

Abstract

The present teachings provide novel polymers, and methods of preparing and using thereof. The novel polymers each includes a sulfide, sulfonyl, or sulfonyl bond. The novel polymer are used to make polycations and/or polyanions, which can be used, for example, to produce adhesive complex coacervates.

Claims

1. A coacervate comprising a polycation and a polyanion, wherein the polycation and/or the polyanion comprises a moiety of Formula II:

2. The coacervate of claim 1, wherein A at each occurrence is O or C(R³)₂.

3. The coacervate of claim 1, wherein at least one A is C(R³)₂, wherein R³ is hydrogen or optionally substituted alkyl.

4. The coacervate of claim 1, wherein at least one A′

is oxygen.

5. The coacervate of claim 1, wherein the moiety of Formula II is of Formula IIIa or Formula IIIb:

6. The coacervate of claim 1, wherein the polycation comprises the moiety of Formula II.

7. The coacervate of claim 6, wherein the polycation comprises one or more amino groups.

8. The coacervate of claim 6, wherein the polycation comprises a peptide or an engineering protein.

9. The coacervate of claim 1, wherein the polyanion comprises the moiety of Formula II.

10. The coacervate of claim 9, wherein the polyanion comprises a sulfate, a sulfonate, a carboxylate, a borate, a boronate, a phosphonate, or a phosphate group.

11. The coacervate of claim 1, wherein the polycation and/or the polyanion is cross-linked.

12. The coacervate of claim 1, wherein the coacervate is an adhesive complex coacervate.