Test apparatus and methods for ST2 cardiac biomarker
First Claim
1. A test apparatus comprising:
- a test strip having a first end and an opposite second end;
a radio frequency identification (RFID) tag configured to store information related to a sample of blood plasma to be dispensed onto the test strip; and
a housing for the test strip, wherein the housing comprises;
a first section comprising an outer face and an inner face, wherein the inner face of the first section comprises a channel to receive the test strip along the length of the first section, anda second section comprising an outer face and an inner face, wherein the second section is configured to be attached to the first section such that in an attached configuration the inner face of the first section faces the inner face of the second section, and the first and second sections together enclose the RFID tag and the test strip within the housing, wherein the second section comprises;
a buffer port configured to allow a buffer solution to be dispensed to a portion of the test strip proximate to the first end of the test strip,a test window configured to facilitate imaging of one or both of a test location and a control location on the test strip,a sample port disposed between the buffer port and the test window, the sample port configured to enable the sample of blood plasma to be dispensed to the test strip, anda set of projections disposed on the inner face of the second section between the test window and the sample port such that in the attached configuration with the first section, each projection in the set of projections is in contact with the test strip and configured to apply pressure on the test strip in accordance with a pressure gradient, wherein a height of at least one projection in the set of projections is different from a height of another projection in the set of projections, and heights of the different projections are configured such that, in the attached configuration, the set of projections produces the pressure gradient within the test strip that allows a fluid to flow at a predetermined flow rate from a portion of the test strip adjacent to the sample port to a portion of the test strip adjacent to the test window along the length of the test strip.
1 Assignment
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Accused Products
Abstract
The technology described in this document can be embodied in a test strip for use in measuring a level of an ST2 cardiac biomarker in a blood plasma sample. The test strip includes a base, and a plurality of conjugates, wherein each conjugate includes a reporter group bound to a first antibody that binds to ST2. A conjugate pad disposed along a length of the base and is configured to hold the plurality of conjugates that bind with ST2 to produce conjugate-ST2 complexes. The conjugate pad is further configured to receive the blood plasma sample. The test strip also includes a plurality of second and third antibodies that bind to ST2, and the conjugate-ST2 complexes, respectively. The plurality of second antibodies are bound to a membrane in a test location and the plurality of third antibodies are bound to the membrane in a control location.
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Citations
11 Claims
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1. A test apparatus comprising:
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a test strip having a first end and an opposite second end; a radio frequency identification (RFID) tag configured to store information related to a sample of blood plasma to be dispensed onto the test strip; and a housing for the test strip, wherein the housing comprises; a first section comprising an outer face and an inner face, wherein the inner face of the first section comprises a channel to receive the test strip along the length of the first section, and a second section comprising an outer face and an inner face, wherein the second section is configured to be attached to the first section such that in an attached configuration the inner face of the first section faces the inner face of the second section, and the first and second sections together enclose the RFID tag and the test strip within the housing, wherein the second section comprises; a buffer port configured to allow a buffer solution to be dispensed to a portion of the test strip proximate to the first end of the test strip, a test window configured to facilitate imaging of one or both of a test location and a control location on the test strip, a sample port disposed between the buffer port and the test window, the sample port configured to enable the sample of blood plasma to be dispensed to the test strip, and a set of projections disposed on the inner face of the second section between the test window and the sample port such that in the attached configuration with the first section, each projection in the set of projections is in contact with the test strip and configured to apply pressure on the test strip in accordance with a pressure gradient, wherein a height of at least one projection in the set of projections is different from a height of another projection in the set of projections, and heights of the different projections are configured such that, in the attached configuration, the set of projections produces the pressure gradient within the test strip that allows a fluid to flow at a predetermined flow rate from a portion of the test strip adjacent to the sample port to a portion of the test strip adjacent to the test window along the length of the test strip. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification