Unobtrusive active eye interrogation

• US 10,080,495 B2
• Filed: 09/26/2014
• Issued: 09/25/2018
• Est. Priority Date: 12/11/2012
• Status: Active Grant

• Current Assignee: Elwha LLC (Intellectual Ventures LLC)
• Original Assignee: Elwha LLC (Intellectual Ventures LLC)
• Inventors: Brown, Jr., Allen L., Burger, Douglas C., Horvitz, Eric, Hyde, Roderick A., Jung, Edward K. Y., Kare, Jordin T., Karkanias, Chris Demetrios, Leuthardt, Eric C., Manferdelli, John L., Mundie, Craig J., Myhrvold, Nathan P., Pell, Barney, Tegreene, Clarence T., Wattenburg, Willard H., Whitmer, Charles, Wood, Jr., Lowell L., Zare, Richard N.
• Primary Examiner(s): THOMAS, BRANDI N
• Application Number:
  US14/497,663
• Publication Number:
  US 20150070653A1
• Time in Patent Office: 1,460 Days
• Field of Search: 351200, 351203, 351205, 351206, 351209-211, 351221, 351222, 351243-246
• CPC Class Codes: A61B 3/0008 provided with illuminating means A61B3/117 takes precedence; goniolenses used for laser treatment A61F9/009; illuminating means for optical instruments G02B27/00
• CPC Class Codes: A61B 3/0025 characterised by electronic signal processing, e.g. eye models
• CPC Class Codes: A61B 3/10 Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
• CPC Class Codes: A61B 3/113 for determining or recording eye movement
• CPC Class Codes: G06V 40/19 Sensors therefor

Abstract

Methods and systems for determining a physiological parameter of a subject through interrogation of an eye of the subject with an optical signal are described. Interrogation is performed unobtrusively. The physiological parameter is determined from a signal sensed from the eye of a subject when the eye of the subject is properly aligned with regard to an interrogation signal source and/or response signal sensor.

Claims

1. A method of measuring information from an eye of a subject, comprising;

delivering an interrogation signal to the eye of the subject with an interrogation signal source;

detecting a response signal from the eye of the subject with a response signal sensor;

determining whether the eye of the subject is in alignment with respect to at least one of the interrogation signal source and the response signal sensor, wherein determining whether the eye of the subject is in alignment with respect to the at least one of the interrogation signal source and the response signal sensor includes determining that the at least one of the interrogation signal source and the response signal sensor lies within a specified number of degrees of a gaze direction of the eye of the subject; and

determining a physiological parameter of the subject from the response signal detected from the eye of the subject when the eye of the subject is in alignment with respect to the at least one of the interrogation signal source and the response signal sensor, including at least one of determining the physiological parameter of the subject from the response signal detected from the eye of the subject at one or more set times and determining the physiological parameter of the subject from the response signal detected from the eye of the subject at a set time interval.

2. The method of claim 1, including:

reporting information regarding the physiological parameter to an interested party.

3. The method of claim 2, wherein the interested party includes one or more of the subject, a medical service provider, a family member, a legal guardian or a legal representative.

4. The method of claim 1, including:

comparing the physiological parameter determined from the response signal to a previous measurement of a physiological parameter to determine a physiological trend.

5. The method of claim 4, including:

reporting information regarding the physiological trend to an interested party.

6. The method of claim 5, wherein the interested party includes one or more of the subject, a medical service provider, a family member, a legal guardian or a legal representative.

7. The method of claim 1, including:

delivering the interrogation signal to the eye of the subject with the interrogation signal source only when the eye of the subject is in alignment with the interrogation signal source and the response signal sensor.

8. The method of claim 1, including:

receiving a signal indicative of the gaze direction of the eye of the subject from a gaze signal sensor.

9. The method of claim 1, wherein the physiological parameter is a measurement of at least one of a substance in the blood of the subject, a substance in an aqueous humor of the subject, oxygen, glucose, a salt, a protein, a lipid, a gas, a measurement of a hormone, a drug, a pulse rate, a blood flow, a temperature.

10. The method of claim 1, including determining the physiological parameter of the subject from the response signal detected from the eye of the subject according to a programmed schedule, wherein the programmed schedule is personalized for the subject, selected from among at least two pre-programmed schedules based upon at least one attribute of the subject, or selected from among at least two pre-programmed schedules based upon the physiological parameter.

11. The method of claim 1, including utilizing the physiological parameter determined from the response signal for at least one of assessing an emotional state of the subject, assessing the alertness of the subject, a medical-related application, health-related application, a business application and security application.

12. The method of claim 1, including:

presenting an input to the subject; and

utilizing the physiological parameter determined from the response signal to determine a response of the subject to the input;

wherein the input includes at least one of information, advertising information, marketing research information, print information, video information, an auditory stimulus, a visual stimulus, a tactile stimulus, an olfactory stimulus, a gustatory stimulus, a thermal stimulus, a neural stimulus, a drug, a pharmaceutical, and a neutraceutical.

13. The method of claim 1, wherein delivering an interrogation signal to the eye of the subject with an interrogation signal source and detecting a response signal from the eye of the subject with a response signal sensor are performed unobtrusively or without detection by the subject.

14. The method of claim 1, including receiving an input indicative of at least one of an instruction, authorization, and informed consent from the subject or representative of the subject for information to be measured.

15. The method of claim 1, including at least one of transmitting at least one of information regarding the subject, information regarding the system used for determining the physiological parameter, or information regarding the physiological parameter to a data processing system;

receiving at least one of information regarding the subject, information regarding the system used for determining the physiological parameter, or information regarding the physiological parameter from a data processing system; and

sharing at least one of information regarding the subject, information regarding the system used for determining the physiological parameter, or information regarding the physiological parameter between two of more data processing systems.

16. The method of claim 1, including determining the identity of the subject through at least one facial recognition, retinal recognition, and comparing login information entered by the subject with login information in a registry.

17. The method of claim 1, including:

determining the identity of the subject; and

delivering the interrogation signal to the eye of the subject with the interrogation signal source only when the identity of the subject meets a selection criterion.

18. The method of claim 1, wherein determining whether the eye of the subject is in alignment with respect to the at least one of the interrogation signal source and the response signal sensor includes determining a quality of the response signal detected with the response signal sensor.

19. The method of claim 1, wherein determining whether the eye of the subject is in alignment with respect to the at least one of the interrogation signal source and the response signal sensor includes determining that the eye of the subject is in alignment with both the interrogation signal source and the response signal sensor.

20. The method of claim 1, including

delivering a gaze tracking stimulus with a gaze tracking stimulus source, the gaze tracking stimulus adapted to cause production of a gaze signal by the eye of the subject;

detecting the gaze signal from the eye of the subject;

determining a gaze direction of the eye of the subject based upon the gaze signal; and

comparing the gaze direction of the eye of the subject with information regarding a position and orientation of the at least one of the interrogation signal source and the response signal sensor.

21. The method of claim 1, including delivering the interrogation signal and detecting the response signal during use by the subject of a device incorporating a display, wherein the interrogation signal source and the response signal sensor are positioned in a housing mounted relative to the display such that the interrogation signal source and response signal sensor are positioned within the visual field of the eye of the subject during the use of the display.

22. The method of claim 21, wherein the device incorporating the display includes a television, a desktop computer, a laptop computer, a tablet computer, a telephone, a wristwatch, a wristband, an armband, a cuff, a sleeve, an article of furniture, an article of exercise equipment, or a vehicle.