Systems and methods for determining and visualizing perfusion of myocardial muscle
First Claim
1. A system for determining and visualizing perfusion of a patient'"'"'s myocardial muscle using computed tomography, comprising:
- a data storage device storing instructions for determining and visualizing perfusion of the patient'"'"'s myocardial muscle using computed tomography; and
a processor configured to execute the instructions to perform a method including;
segmenting (1) coronary blood vessels having vulnerable plaque and (2) myocardial muscle, from non-invasively produced patient-specific CT image data of a patient'"'"'s heart;
generating a patient-specific three-dimensional model of blood flow through the coronary blood vessels segmented from the patient-specific image data;
simulating, non-invasively, a blood flow through the coronary blood vessels of the patient-specific three-dimensional model, and determining from the simulation, blood flow into different regions of the myocardial muscle into which different branches of the coronary blood vessels lead;
simulating, non-invasively, a patient-specific local perfusion of the myocardial muscle for the different regions on the basis of the determined blood flow into the different regions of the myocardial muscle and the three-dimensional model;
determining one or more regions that are at risk of insufficient perfusion using the simulated patient-specific local perfusion of the different regions of the myocardial muscle and blood flow through coronary blood vessels having vulnerable plaque, wherein a region is at risk of insufficient perfusion if it comprises a quantifiable loss in local perfusion due to the vulnerable plaque; and
generating a visualization of the myocardial muscle, from which the patient-specific local perfusion of the different regions of the myocardial muscle, the one or more regions that are at risk of insufficient perfusion, and the coronary blood vessels leading to the one or more regions that are at risk of insufficient perfusion are identifiable.
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Abstract
Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient'"'"'s heart, and create a three-dimensional model representing at least a portion of the patient'"'"'s heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient'"'"'s heart and determine a fractional flow reserve within the patient'"'"'s heart based on the three-dimensional model and the physics-based model.
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Citations
17 Claims
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1. A system for determining and visualizing perfusion of a patient'"'"'s myocardial muscle using computed tomography, comprising:
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a data storage device storing instructions for determining and visualizing perfusion of the patient'"'"'s myocardial muscle using computed tomography; and a processor configured to execute the instructions to perform a method including; segmenting (1) coronary blood vessels having vulnerable plaque and (2) myocardial muscle, from non-invasively produced patient-specific CT image data of a patient'"'"'s heart; generating a patient-specific three-dimensional model of blood flow through the coronary blood vessels segmented from the patient-specific image data; simulating, non-invasively, a blood flow through the coronary blood vessels of the patient-specific three-dimensional model, and determining from the simulation, blood flow into different regions of the myocardial muscle into which different branches of the coronary blood vessels lead; simulating, non-invasively, a patient-specific local perfusion of the myocardial muscle for the different regions on the basis of the determined blood flow into the different regions of the myocardial muscle and the three-dimensional model; determining one or more regions that are at risk of insufficient perfusion using the simulated patient-specific local perfusion of the different regions of the myocardial muscle and blood flow through coronary blood vessels having vulnerable plaque, wherein a region is at risk of insufficient perfusion if it comprises a quantifiable loss in local perfusion due to the vulnerable plaque; and generating a visualization of the myocardial muscle, from which the patient-specific local perfusion of the different regions of the myocardial muscle, the one or more regions that are at risk of insufficient perfusion, and the coronary blood vessels leading to the one or more regions that are at risk of insufficient perfusion are identifiable. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for simulating a perfusion of a myocardial muscle, comprising:
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segmenting (1) coronary blood vessels having vulnerable plaque and (2) myocardial muscle, from non-invasively produced patient-specific CT image data of a patient'"'"'s heart; generating a patient-specific three-dimensional model of blood flow through the coronary blood vessels segmented from the patient-specific image data; simulating, non-invasively, a blood flow through the coronary blood vessels of the patient-specific three-dimensional model, and determining from the simulation, blood flow into different regions of the myocardial muscle into which different branches of the coronary blood vessels lead; simulating, non-invasively, a patient-specific local perfusion of the myocardial muscle for the different regions on the basis of the determined blood flow into the different regions of the myocardial muscle and the three-dimensional model; determining one or more regions that are at risk of insufficient perfusion using the simulated patient-specific local perfusion of the different regions of the myocardial muscle and blood flow through coronary blood vessels having vulnerable plaque, wherein a region is at risk of insufficient perfusion if it comprises a quantifiable loss in local perfusion due to the vulnerable plaque; and generating a visualization of the myocardial muscle, from which the patient-specific local perfusion of the different regions of the myocardial muscle, the one or more regions that are at risk of insufficient perfusion, and the coronary blood vessels leading to the one or more regions that are at risk of insufficient perfusion are identifiable. - View Dependent Claims (14, 15, 16)
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17. A non-transitory computer readable medium storing instructions, when executed by a processor, cause the processor to:
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segment (1) coronary blood vessels having vulnerable plaque and (2) myocardial muscle, from non-invasively produced patient-specific CT image data of a patient'"'"'s heart; generate a patient-specific three-dimensional model of blood flow through the coronary blood vessels segmented from the patient-specific CT image data; simulate, non-invasively, a blood flow through the coronary blood vessels of the patient-specific three-dimensional model, and determining from the simulation, blood flow into different regions of the myocardial muscle into which different branches of the coronary blood vessels lead; simulate, non-invasively, a patient-specific local perfusion of the myocardial muscle for the different regions on the basis of the determined blood flow into the different regions of the myocardial muscle and the three-dimensional model; determine one or more regions that are at risk of insufficient perfusion using the simulated patient-specific local perfusion of the different regions of the myocardial muscle and blood flow through coronary blood vessels having vulnerable plaque, wherein a region is at risk of insufficient perfusion if it comprises a quantifiable loss in local perfusion due to the vulnerable plaque; and generate a visualization of the myocardial muscle, from which the patient-specific local perfusion of the different regions of the myocardial muscle, the one or more regions that are at risk of insufficient perfusion, and the coronary blood vessels leading to the one or more regions that are at risk of insufficient perfusion are identifiable.
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Specification