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Treatment of vasculopathy with prostacyclin and mesenchymal stem cells

  • US 10,080,730 B2
  • Filed: 01/08/2014
  • Issued: 09/25/2018
  • Est. Priority Date: 01/09/2013
  • Status: Active Grant
First Claim
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1. A pharmaceutical composition comprising a pharmaceutically effective amount of a mesenchymal stem cell culture and a pharmaceutically acceptable carrier, wherein the mesenchymal stem cell culture comprises treprostinil or a pharmaceutically acceptable salt or ester thereof and is prepared by a method comprising culturing a mesenchymal stem cell in a culture medium and adding an amount of treprostinil or a pharmaceutically acceptable salt or ester thereof to the culture medium during culturing of the mesenchymal stem cell sufficient to increase the amount of vascular endothelial growth factor contained in the mesenchymal stem cell culture.

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