Method for treating autism and other neurodevelopmental disorders

• US 10,080,734 B2
• Filed: 10/24/2017
• Issued: 09/25/2018
• Est. Priority Date: 07/26/2012
• Status: Active Grant

• Current Assignee: The William M. Yarbrough Foundation
• Original Assignee: The William M. Yarbrough Foundation
• Inventors: Silver, Michael E.
• Primary Examiner(s): Henley, III, Raymond J
• Application Number:
  US15/792,097
• Publication Number:
  US 20180042885A1
• Time in Patent Office: 336 Days
• Field of Search: 514562, 514629, 514638
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/13 Amines A61K31/04 takes precedence
• CPC Class Codes: A61K 31/16 Amides, e.g. hydroxamic acids
• CPC Class Codes: A61K 31/197 the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid carnitine A61K31/205
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/26 Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
• CPC Class Codes: A61K 31/4172 Imidazole-alkanecarboxylic acids, e.g. histidine
• CPC Class Codes: A61K 31/454 containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• CPC Class Codes: A61K 38/1793 for cytokines; for lymphokines; for interferons
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: C07C 331/20 of a saturated carbon skeleton

Abstract

A method for treating autism and other neurodevelopmental disorders including the step of administering an effective amount of an isothiocyanate functional surfactant to a human, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant. The administration of the isothiocyanate functional surfactant may be augmented with a NMDA-receptor antagonist and/or a TNF-α inhibiting agent.

Claims

1. A method for treating autism or other neurodevelopmental disorders, comprising the step(s) of:

administering to a patient in need thereof an effective amount of an isothiocyanate functional surfactant, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.

2. The method for treating autism or other neurodevelopmental disorders according to claim 1, further comprising the step of administering a NMDA-receptor antagonist to the patient.

3. The method for treating autism or other neurodevelopmental disorders according to claim 2, wherein the NMDA-receptor antagonist comprises 1-amino-3,5-dimethyladamantane or a pharmaceutically acceptable salts thereof.

4. The method for treating autism or other neurodevelopmental disorders according to claim 2, further comprising the step of administering a TNF-α

inhibiting agent to the patient.

5. The method for treating autism or other neurodevelopmental disorders according to claim 4, wherein the TNF-α

inhibiting agent is selected from at least one of Lenalinomide, Thalidomide, L-Camosine, Infliximab, Etanercept, a stem cell preparation, isomers thereof, or pharmaceutically acceptable salts thereof.

6. The method for treating autism or other neurodevelopmental disorders according to claim 1, further comprising the step of administering a TNF-α

inhibiting agent to the patient.

7. The method for treating autism or other neurodevelopmental disorders according to claim 6, wherein the TNF-α

inhibiting agent is selected from at least one of Lenalinomide, Thalidomide, L-Camosine, Infliximab, Etanercept, a stem cell preparation, isomers thereof, or pharmaceutically acceptable salts thereof.

8. A method for treating autism or other neurodevelopmental disorders, comprising the step(s) of:

administering to a patient in need thereof an effective amount of a lysine derivative, wherein the lysine derivative comprises an α

-nitrogen and a ε

-nitrogen, and wherein an alkyl and/or alkanoyl substituent comprising at least approximately 8 carbon atoms is associated with the α

-nitrogen, and further wherein at least one isothiocyanate functional group is associated with the ε

-nitrogen.

9. The method for treating autism or other neurodevelopmental disorders according to claim 8, further comprising the step of administering a NMDA-receptor antagonist to the patient.

10. The method for treating autism or other neurodevelopmental disorders according to claim 8, further comprising the step of administering a TNF-α

inhibiting agent to the patient.

11. A method for treating autism or other neurodevelopmental disorders, comprising the step(s) of:

administering to a patient in need thereof an effective amount of a surfactant or a pharmaceutically acceptable salt thereof, wherein the protonated form of the surfactant is represented by the following chemical structure;

12. The method for treating autism or other neurodevelopmental disorders, according to claim 11, wherein the protonated form of the surfactant is represented by the following chemical structure:

13. The method for treating autism or other neurodevelopmental disorders, according to claim 11, wherein the protonated form of the surfactant is represented by the following chemical structure:

14. The method for treating autism or other neurodevelopmental disorders according to claim 13, further comprising the step of administering a NMDA-receptor antagonist to the patient.

15. The method for treating autism or other neurodevelopmental disorders according to claim 14, wherein the NMDA-receptor antagonist comprises 1-amino-3,5-dimethyladamantane or a pharmaceutically acceptable salts thereof.

16. The method for treating autism or other neurodevelopmental disorders according to claim 11, further comprising the step of administering a TNF-α

inhibiting agent to the patient.

17. The method for treating autism or other neurodevelopmental disorders according to claim 16, wherein the TNF-α

inhibiting agent is selected from at least one of Lenalinomide, Thalidomide, L-Camosine, Infliximab, Etanercept, a stem cell preparation, isomers thereof, or pharmaceutically acceptable salts thereof.

18. The method for treating autism or other neurodevelopmental disorders, according to claim 11, wherein the deprotonated form of the surfactant is represented by the following chemical structure:

19. The method for treating autism or other neurodevelopmental disorders, according to claim 11, further comprising the step of administering an additional surfactant, wherein the additional surfactant is selected from at least one of the group comprising a non-ionic surfactant, an anionic surfactant, a cationic surfactant, a zwitterionic surfactant, and combinations thereof.

20. The method for treating autism or other neurodevelopmental disorders, according to claim 11, wherein R₁ is selected from the group consisting of an alkyl, aryl, alkoxy, alkanoyl, aroyl, alkenyl, and cyano group containing 1 to approximately 25 carbon atom(s);

wherein R2 is NCS; and

wherein R3-R5 are each independently selected from the group consisting of H, OH, and an alkyl, aryl, alkoxy, alkanoyl, aroyl, alkenyl, and cyano group containing 1 to approximately 25 carbon atom(s) with the proviso that at least one of R3-R5 is selected from the group consisting of an alkyl, aryl, alkoxy, alkanoyl, aroyl, alkenyl, and cyano group containing approximately 8 to approximately 25 carbon atom(s).

21. The method for treating autism or other neurodevelopmental disorders, according to claim 18, wherein R₁ is selected from the group consisting of an alkyl, aryl, alkoxy, alkanoyl, aroyl, alkenyl, and cyano group containing 1 to approximately 25 carbon atom(s);

wherein R2 is NCS; and

wherein R3-R5 are each independently selected from the group consisting of H, OH, and an alkyl, aryl, alkoxy, alkanoyl, aroyl, alkenyl, and cyano group containing 1 to approximately 25 carbon atom(s) with the proviso that at least one of R3-R5 is selected from the group consisting of an alkyl, aryl, alkoxy, alkanoyl, aroyl, alkenyl, and cyano group containing approximately 8 to approximately 25 carbon atom(s), and wherein X is a counter cation.