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Nucleation of drug delivery balloons to provide improved crystal size and density

  • US 10,080,821 B2
  • Filed: 06/14/2010
  • Issued: 09/25/2018
  • Est. Priority Date: 07/17/2009
  • Status: Active Grant
First Claim
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1. A method of making a drug delivery balloon having a coating thereon comprising a drug, the balloon made of a balloon material, the drug selected from the group consisting of paclitaxel, paclitaxel analogs and paclitaxel derivatives,wherein the drug has a characteristic amorphous form and a crystalline form comprising:

  • a) applying a coating of the drug in the amorphous form to the balloon material, and, subsequent to applying the coating,b) annealing with a solvent vapor the coating which has been applied in step a), the solvent vapor comprising an alcohol, to produce the crystalline form of the drug on the balloon,wherein in the applying step a) the drug coating is applied to a balloon surface that has been nucleated by blooming of a component in the balloon material to the surface thereof, the component crystallizing at the surface of the balloon material as a result of the blooming to induce formation of drug crystals in the annealing step.

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