Substrates for nitric oxide releasing devices

• US 10,080,823 B2
• Filed: 11/17/2010
• Issued: 09/25/2018
• Est. Priority Date: 10/30/2007
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Inventors: Hyde, Roderick A., Ishikawa, Muriel Y., Stordal, Leif T., Wood, Jr., Lowell L.
• Primary Examiner(s): HAWTHORNE, OPHELIA ALTHEA
• Application Number:
  US12/927,610
• Publication Number:
  US 20110166536A1
• Time in Patent Office: 2,869 Days
• Field of Search: 422 98, 422186, 4221863, 4352861, 436 55, 600 40, 600377, 602 1, 602 40, 602 41, 604 23, 604500, 607 88, 702 24
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61L 2300/114 Nitric oxide, i.e. NO
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: Y10T 29/49826 Assembling or joining

Abstract

The present disclosure relates to substrates associated with nitric oxide.

Claims

1. An apparatus comprising:

at least one light permeable substrate having a first surface configured to be positioned proximate a skin surface of a subject and having one or more photolyzable nitric oxide donors operatively coupled thereto, and a second surface opposite from the first surface; and

at least one light emitting diode operatively coupled to the at least one light permeable substrate and operable to emit light onto at least a portion of the second surface of the at least one light permeable substrate to cause light to pass through the at least one light permeable substrate that facilitates release of nitric oxide from the one or more photolyzable nitric oxide donors coupled with the first surface proximate the skin surface of the subject.

2. The apparatus of claim 1, further comprising:

one or more of the following types of sensors operatively coupled with the at least one control unit;

nitric oxide, temperature, pressure, pulse rate, bacteria, strain, or light.

3. The apparatus of claim 1, further comprising:

one or more electromagnetic receivers and/or transmitters operatively coupled with the at least one control unit.

4. The apparatus of claim 1, wherein the apparatus is configured as a wearable article that wraps around at least one portion of an individual.

5. The apparatus of claim 1, further comprising:

one or more energy sources operatively coupled with the at least one control unit.

6. The apparatus of claim 1, further comprising:

at least one electromagnetic receiver operatively coupled with the at least one control unit and operable to facilitate remote control of the at least one light emitting diode.

7. The apparatus of claim 1, further comprising:

at least one electromagnetic receiver operatively coupled with the at least one light emitting diode and operable to receive one or more instructions associated with one or more of the following types of operations associated with the at least one light emitting diode;

emission, non-emission, time, length, intensity, or wavelength.

8. The apparatus of claim 1, wherein the at least one light emitting diode is operable to emit light via one or more of the following ways:

continuous, pulse, or flash.

9. The apparatus of claim 1, further comprising:

at least one of the following types of user interfaces operatively coupled with the at least one control unit;

on/off switch, push button, or key.

10. The apparatus of claim 1, wherein the at least one control unit is configured to regulate one or more of the following with respect to the at least one light emitting diode:

emission, intensity, duration, frequency, wavelength, or time.

11. The apparatus of claim 1, wherein the at least one light permeable substrate comprises one or more of the following materials:

metal, metal alloy, polymer, copolymer, ceramic, cloth, or fabric.

12. The apparatus of claim 1, wherein the at least one light permeable substrate comprises at least one elastomeric portion.

13. The apparatus of claim 1, wherein the at least one substrate at least partially encloses the at least one light emitting diode and/or the at least one control unit.

14. The apparatus of claim 1, further comprising:

at least one status indicator operatively coupled with at least one of the at least one light permeable substrate, the at least one light emitting diode, or the at least one control unit, the at least one status indicator being operable to indicate a status of at least one photolyzable nitric oxide donor, the at least one light emitting diode, or the at least one control unit.

15. The apparatus of claim 1, wherein the at least one light permeable substrate includes at least one wrap portion configured to be wrapped around one or more portions of an individual,

wherein the at least one light emitting diode is operable to emit blue light that facilitates release of nitric oxide from one or more photolyzable nitric oxide donors,

wherein the apparatus further comprises at least one receiver operatively coupled with at least one control unit and that is operable to receive one or more wireless signals to facilitate remote control of one or more operations, and

wherein the at least one control unit is configured to at least turn the at least one light emitting diode off after at least one predetermined amount of time has elapsed.

16. The apparatus of claim 1, wherein the

one or more photolyzable nitric oxide donors are at least one of disposed on the first surface of, or integrally formed with the first surface of, the at least one light permeable substrate.

17. The apparatus of claim 1, wherein the at least one light emitting diode is operable to emit one or more of the following types of light:

red, green, orange, yellow, blue, or white.

18. The apparatus of claim 1, wherein the at least one light emitting diode is operable to emit one or more of the following types of light:

infrared, visible, near-ultraviolet, or ultraviolet.

19. An apparatus comprising:

at least one light permeable substrate having a first surface configured to be positioned proximate a skin surface of a subject, and a second surface opposite from the first surface;

at least one photolyzable nitric oxide donor that is operatively coupled with the first surface of the at least one light permeable substrate and that is operable to release nitric oxide in response to light; and

at least one control unit operatively coupled to the at least one light permeable substrate and configured to control a permeability of the at least one light permeable substrate to cause light passing through the at least one light permeable substrate to activate release of nitric oxide from the at least one photolyzable nitric oxide donor coupled with the first surface proximate the skin surface of the subject.

20. An apparatus comprising:

at least one light permeable substrate having a first surface configured to be positioned proximate a skin surface of a subject, and a second surface opposite from the first surface;

at least one photolyzable nitric oxide donor that is operatively coupled with the first surface of the at least one light permeable substrate and that is operable to release nitric oxide in response to light; and

at least one optical waveguide configured to guide a photolyzing light onto the second surface of the at least one light permeable substrate to cause light passing through the at least one light permeable substrate to activate release of nitric oxide from the at least one photolyzable nitric oxide donor coupled with the first surface proximate the skin surface of the subject.

21. An apparatus comprising:

at least one light permeable substrate having a first surface configured to be positioned proximate a skin surface of a subject, and a second surface opposite from the first surface;

least one photolyzable nitric oxide donor that is operatively coupled with the first surface of the at least one light permeable substrate and that is operable to release nitric oxide in response to light; and

one or more solar cells operatively coupled to the at least one light permeable substrate and configured to provide power to facilitate light passing through the at least one light permeable substrate to activate release of nitric oxide from the at least one photolyzable nitric oxide donor coupled with the first surface proximate the skin surface of the subject.

22. An apparatus comprising:

at least one light permeable substrate having a first surface configured to be positioned proximate a skin surface of a subject, and a second surface opposite from the first surface;

at least one photolyzable nitric oxide donor that is operatively coupled with the first surface of the at least one light permeable substrate and that is operable to release nitric oxide in response to light; and

at least one status indicator operatively coupled with the at least one light permeable substrate and operable to indicate a status of at least one of the at least one photolyzable nitric oxide donor or nitric oxide released by the at least one photolyzable nitric oxide donor as light passing through the at least one light permeable substrate activates release of nitric oxide from the at least one photolyzable nitric oxide donor coupled with the first surface proximate the skin surface of the subject.