Extra-cardiovascular cardiac pacing system

• US 10,080,891 B2
• Filed: 12/03/2015
• Issued: 09/25/2018
• Est. Priority Date: 12/03/2015
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Thompson-Nauman, Amy E., Christie, Melissa G. T., Marshall, Mark T., Spear, Thomas H.
• Primary Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US14/957,651
• Publication Number:
  US 20170157395A1
• Time in Patent Office: 1,027 Days
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/3706 Pacemaker parameters stimulation threshold A61N1/371
• CPC Class Codes: A61N 1/3925 Monitoring; Protecting
• CPC Class Codes: A61N 1/3956 Implantable devices for applying electric shocks to the heart, e.g. for cardioversion

Abstract

An extra-cardiovascular medical device is configured to select a capacitor configuration from a capacitor array and deliver a low voltage, pacing pulse by discharging the selected capacitor configuration across an extra-cardiovascular pacing electrode vector. In some examples, the medical device is configured to determine the capacitor configuration based on a measured impedance of the extra-cardiovascular pacing electrode vector.

Claims

1. An extra-cardiovascular medical device, comprising:

an impedance measurement module configured to measure an impedance of an extra-cardiovascular pacing electrode vector when extra-cardiovascular pacing electrodes are electrically coupled to the medical device;

a therapy delivery module comprising a capacitor array having a plurality of capacitors for producing a pacing pulse; and

a pacing control module coupled to the therapy delivery module and the impedance measurement module and configured to;

control the impedance measurement module to measure the impedance of the extra-cardiovascular pacing electrode vector;

determine a first capacitor configuration based on the measured impedance by determining a capacitance required for the measured impedance to produce an RC time constant that is greater than a time interval threshold and identifying the first capacitor configuration so that the first capacitance is equal to or greater than the determined capacitance, the first capacitor configuration comprising a first combination of the plurality of capacitors having a first capacitance;

control the therapy delivery module to select the first capacitor configuration by selectively enabling the first combination of the plurality of capacitors of the capacitor array; and

control the therapy delivery module to deliver a cardiac pacing pulse by discharging the first capacitor configuration for a predetermined pulse width across the extra-cardiovascular pacing electrode vector.

2. The device of claim 1, wherein the time interval threshold is greater than the pacing pulse width.

3. The device of claim 1, wherein:

the therapy delivery module is configured to sample the amplitude of the pacing pulse during a first portion of the pulse width and during a second portion of the pulse width after the first portion; and

the pacing control module is further configured to;

receive the sampled pacing pulse amplitude from the therapy delivery module;

compare the sampled pacing pulse amplitude to a first threshold during the first portion of the pulse width;

in response to the sampled pacing pulse amplitude being greater than the first threshold, continue delivering the pacing pulse using the first capacitor configuration;

compare the sampled pacing pulse amplitude to a second threshold during the second portion of the pulse width, the second threshold lower than the first threshold;

determine a second capacitor configuration in response to the pacing pulse amplitude being less than or equal to the second threshold during the second portion of the pulse width, the second capacitor configuration comprising a second combination of the plurality of capacitors of the capacitor array;

control the therapy delivery module to select the second capacitor configuration by selectively enabling the second combination of the plurality of capacitors of the capacitor array; and

control the therapy delivery module to continue delivering the pacing pulse by discharging the second capacitor configuration during the second portion of the pulse width.

4. The device of claim 1, wherein:

the therapy delivery module is configured to sample the amplitude of the pacing pulse; and

the pacing control module is further configured to;

receive the sampled pacing pulse amplitude from the therapy delivery module;

compare the sampled pacing pulse amplitude to an amplitude threshold;

in response to the sampled pacing pulse amplitude being greater than the amplitude threshold, adjust the first capacitor configuration to a second combination of the plurality of capacitors of the capacitor array, the second combination having a second capacitance less than the first capacitance;

control the therapy delivery module to enable the adjusted first capacitor configuration by selectively enabling the second combination of the plurality of capacitors of the capacitor array; and

control the therapy delivery module to deliver a next pacing pulse by discharging the adjusted first capacitor configuration for the predetermined pulse width.

5. The device of claim 1, further comprising a memory storing a plurality of impedance ranges and a plurality of capacitor configurations, wherein one of the plurality of capacitor configurations is stored for each one of the plurality of impedance ranges,

wherein the pacing control module is configured to determine the first capacitor configuration by matching the measured impedance to one of the plurality of impedance ranges and selecting the capacitor configuration stored for the matching impedance range.

6. An extra-cardiovascular medical device comprising:

an impedance measurement module configured to measure an impedance of an extra-cardiovascular pacing electrode vector when extra-cardiovascular pacing electrodes are electrically coupled to the medical device;

a therapy delivery module comprising a capacitor array having a plurality of capacitors for producing a pacing pulse; and

a pacing control module coupled to the therapy delivery module and the impedance measurement module and configured to;

control the impedance measurement module to measure the impedance of the extra-cardiovascular pacing electrode vector;

determine a first capacitor configuration based on the measured impedance, the first capacitor configuration comprising a first combination of the plurality of capacitors having a first capacitance;

control the therapy delivery module to select the first capacitor configuration by selectively enabling the first combination of the plurality of capacitors of the capacitor array; and

control the therapy delivery module to deliver a cardiac pacing pulse by discharging the first capacitor configuration for a predetermined pulse width across the extra-cardiovascular pacing electrode vector, wherein

the therapy delivery module is configured to sample the amplitude of the pacing pulse after a first portion of the pulse width; and

the pacing control module is further configured to;

receive the sampled pacing pulse amplitude from the therapy delivery module;

compare the sampled pacing pulse amplitude to a first amplitude threshold;

determine a second capacitor configuration in response to the sampled pacing pulse amplitude being less than or equal to the first amplitude threshold;

control the therapy delivery module to select the second capacitor configuration by selectively enabling the second combination of the plurality of capacitors of the capacitor array; and

control the therapy delivery module to continue delivering the pacing pulse by discharging the second capacitor configuration during a second portion of the pulse width, the second portion after the first portion.

7. The device of claim 6, wherein the second capacitor configuration is selected to have a second capacitance that is greater than the first capacitance.

8. The device of claim 6, wherein the pacing control module is configured to set the first amplitude threshold to a percentage of a leading edge amplitude of the pacing pulse.

9. The device of claim 6, wherein the second capacitor configuration comprises the first capacitor configuration and at least one capacitor of the plurality of capacitors that was not included in the first capacitor configuration.

10. The device of claim 6, wherein:

the therapy delivery module is configured to sample the amplitude of the pacing pulse during the second portion of the pulse width; and

the pacing control module is further configured to;

compare the amplitude of the pacing pulse during the second portion of the pulse width to a second amplitude threshold; and

control the impedance measurement module to repeat the measurement of the impedance of the pacing electrode vector in response to the amplitude of the pacing pulse being less than the second amplitude threshold during the second portion of the pulse width.

11. A method performed by an extra-cardiovascular medical device, comprising:

measuring an impedance of an extra-cardiovascular pacing electrode vector when extra-cardiovascular pacing electrodes are electrically coupled to the medical device;

determining by a pacing control module of the medical device a first capacitor configuration based on the measured impedance by determining a capacitance required for the measured impedance to produce an RC time constant that is greater than a time interval threshold and identifying the first capacitor configuration so that the first capacitance is equal to or greater than the determined capacitance, the first capacitor configuration comprising a first combination of a plurality of capacitors of a capacitor array;

selecting the first capacitor configuration by selectively enabling the first combination of the plurality of capacitors; and

delivering a cardiac pacing pulse by discharging the first capacitor configuration for a predetermined pulse width across the extra-cardiovascular pacing electrode vector.

12. The method of claim 11, wherein the time interval threshold is greater than the pacing pulse width.

13. The method of claim 11, further comprising

sampling the amplitude of the pacing pulse during a first portion of the pulse width and during a second portion of the pulse width after the first portion;

receiving the sampled pacing pulse amplitude from the therapy delivery module;

comparing the sampled pacing pulse amplitude to a first threshold during the first portion of the pulse width;

in response to the sampled pacing pulse amplitude being greater than the first threshold, continuing delivering the pacing pulse using the first capacitor configuration;

comparing the sampled pacing pulse amplitude to a second threshold during the second portion of the pulse width, the second threshold lower than the first threshold;

determining a second capacitor configuration in response to the pacing pulse amplitude being less than or equal to the second threshold during the second portion of the pulse width, the second capacitor configuration comprising a second combination of the plurality of capacitors of the capacitor array and having a second capacitance greater than the first capacitance;

selecting the second capacitor configuration by selectively enabling the second combination of the plurality of capacitors of the capacitor array; and

continuing delivering the pacing pulse by discharging the second capacitor configuration during the second portion of the pulse width.

14. The method of claim 11, further comprising:

sampling the amplitude of the pacing pulse;

comparing the sampled pacing pulse amplitude to an amplitude threshold;

in response to the sampled pacing pulse amplitude being greater than the amplitude threshold, adjusting the first capacitor configuration to a second combination of the plurality of capacitors of the capacitor array, the second combination having a second capacitance less than the first capacitance;

enabling the adjusted first capacitor configuration by selectively enabling the second combination of the plurality of capacitors of the capacitor array; and

delivering a next pacing pulse by discharging the adjusted first capacitor configuration for the predetermined pulse width.

15. The method of claim 11, further comprising:

storing in a memory of the medical device a plurality of impedance ranges and a plurality of capacitor configurations, wherein one of the plurality of capacitor configurations is stored for each one of the plurality of impedance ranges; and

determining the first capacitor configuration by matching the measured impedance to one of the plurality of impedance ranges and selecting the capacitor configuration stored for the matching impedance range.

16. A method comprising:

measuring an impedance of an extra-cardiovascular pacing electrode vector when extra-cardiovascular pacing electrodes are electrically coupled to the medical device;

determining by a pacing control module of the medical device a first capacitor configuration based on the measured impedance by determining a capacitance required for the measured impedance to produce an RC time constant that is greater than a time interval threshold and identifying the first capacitor configuration so that the first capacitance is equal to or greater than the determined capacitance, the first capacitor configuration comprising a first combination of a plurality of capacitors of a capacitor array;

selecting the first capacitor configuration by selectively enabling the first combination of the plurality of capacitors; and

delivering a cardiac pacing pulse by discharging the first capacitor configuration for a predetermined pulse width across the extra-cardiovascular pacing electrode vector;

sampling the amplitude of the pacing pulse after a first portion of the pulse width;

comparing the sampled pacing pulse amplitude to a first amplitude threshold;

determining a second capacitor configuration in response to the sampled pacing pulse amplitude being less than or equal to the first amplitude threshold;

selecting the second capacitor configuration by selectively enabling the second combination of the plurality of capacitors of the capacitor array; and

continuing delivering the pacing pulse by discharging the second capacitor configuration during a second portion of the pulse width, the second portion after the first portion.

17. The method of claim 16, wherein determining the second capacitor configuration comprises determining a second capacitance of the second capacitor configuration that is greater than the first capacitance of the first capacitor configuration.

18. The method of claim 16, further comprising setting the first amplitude threshold to a percentage of a leading edge amplitude of the pacing pulse.

19. The method of claim 16, further comprising selecting the second capacitor configuration by selecting the first capacitor configuration and at least one capacitor of the plurality of capacitors that was not included in the first capacitor configuration.

20. The method of claim 16, further comprising:

sampling the amplitude of the pacing pulse during the second portion of the pulse width;

comparing the amplitude of the pacing pulse during the second portion of the pulse width to a second amplitude threshold; and

repeating the impedance measurement of the pacing electrode vector in response to the amplitude of the pacing pulse being less than the second amplitude threshold during the second portion of the pulse width.