Systems and methods for neuromodulation device coding with trans-species libraries

• US 10,080,894 B2
• Filed: 06/18/2015
• Issued: 09/25/2018
• Est. Priority Date: 06/18/2014
• Status: Active Grant

• Current Assignee: Northwestern University, Resonance Medical, LLC
• Original Assignee: Northwestern University, Resonance Medical, LLC
• Inventors: Richter, Claus-Peter, Heddon, Chris, LaFaire, Petrina, Dougherty, Brian
• Primary Examiner(s): Hulbert, Amanda
• Assistant Examiner(s): Dinga, Roland
• Application Number:
  US14/743,478
• Publication Number:
  US 20150367131A1
• Time in Patent Office: 1,195 Days
• Field of Search: 607 55, 607 57, 607137, 607116
• CPC Class Codes: A61N 1/0541 Cochlear electrodes
• CPC Class Codes: A61N 1/36038 Cochlear stimulation

Abstract

Aspects of the invention include systems and methods for neuromodulation device coding with a neural code library. The method includes identifying a pattern of a sensory signal, retrieving one or more digital representations of a neural response corresponding to the identified pattern from a neural code library, where the neural code library comprises a plurality of digital representations of neural responses of neural units corresponding to each pattern, selecting one or more neural units of a patient to be stimulated by a neuromodulation device associated with the patient based on the retrieved one or more digital representations of a neural response pattern, and stimulating the selected neural units of the patient.

Claims

1. A method for neuromodulation device coding for stimulation of a patient, comprising:

(a) identifying, by an analyzer, a pattern of a sensory signal;

(b) retrieving, by a processing device, one or more digital representations of a neural response corresponding to the identified pattern from a neural code library, wherein the neural code library comprises a plurality of digital representations of neural responses of neural units of at least one normal functioning animal, wherein each of the plurality of digital representations of neural responses corresponds to one of a plurality of digital representations of acoustic patterns;

(c) selecting, by the processing device, one or more neural units of the patient to be stimulated by a neuromodulation device associated with the patient based on the retrieved one or more digital representations of a neural response pattern; and

(d) stimulating, by a transmitting device in communication with the processing device and the neuromodulation device, the selected neural units of the patient.

2. The method of claim 1, wherein the neuromodulation device is implanted in the patient.

3. The method of claim 2, wherein the neuromodulation device is a cochlear implant.

4. The method of claim 1, wherein each neural unit is an identifiable and stable single unit in at least one of the inferior colliculus, cochlear nucleus, auditory nerve, cortex, brainstem, and midbrain of the normal functioning animal.

5. The method of claim 1, wherein the neural responses of neural units of the normal functioning animal are acquired from neural recordings in the neural units when each pattern is played to the normal functioning animal at a plurality of frequencies.

6. The method of claim 5, wherein each neural response pattern contains a sequence of neural responses of a corresponding neural unit at its corresponding best frequency to the identified pattern.

7. The method of claim 6, wherein the neural response of each neural unit of the normal functioning animal comprises a train of action potentials generated in the neural unit of the normal functioning animal in response to the receipt of the identified pattern.

8. The method of claim 7, wherein the selected neural units of the patient are simulated with electrical pulses that are coincident with the trains of action potentials generated in the corresponding neural units of the normal functioning animal in response to the receipt of the identified pattern.

9. The method of claim 1, wherein the pattern is a segment or a frame of the sensory signal.

10. The method of claim 9, wherein the sensory signal is an acoustic signal.

11. The method of claim 10, wherein the pattern comprises a phoneme, a syllable, a word, words, or a combination thereof.

12. The method of claim 1, further comprising repeating steps (a)-(d) consecutively for each pattern of the sensory signal.

13. The method of claim 10, wherein the step of identifying the pattern of the sensory signal is performed with a speech recognition algorithm.

14. The method of claim 1, wherein the step of retrieving one or more digital representations of a neural response corresponding to the identified pattern from the neural code library is performed with a stochastic model including a Hidden Markov Model (HMM).

15. The method of claim 1, further comprising optimizing the selection of the units for stimulation optimization based on feedback from the patient.

16. A system for cochlear implant coding for stimulation of a patient, comprising:

(a) a neural code library comprising a plurality of digital representations of neural responses of neural units of at least one normal hearing animal, wherein each of the plurality of digital representations of neural responses corresponds to one of a plurality of digital representations of acoustic patterns;

(b) a sensory device configured to detect an acoustic signal;

(c) an analyzer in communication with the sensory device, configured to identify one of the digital representations of acoustic patterns in the neural code library in response to the receipt of the acoustic signal;

(d) a processing device in communication with the neural code library and the analyzer, configured, for each identified acoustic pattern, to

retrieve the digital representations of neural responses of neural units corresponding to the identified acoustic pattern from the neural code library; and

select one or more neural units of the patient to be stimulated by a cochlear implant implanted in the patient; and

(e) a transmitting device in communication with the processing device and the cochlear implant, configured to stimulate the selected one or more neural units of the patient.

17. The system of claim 16, wherein the digital representations of the neural responses include data for each of a plurality of frequencies.

18. The system of claim 17, wherein each neural response pattern contains a sequence of neural responses of a corresponding neural unit at its corresponding best frequency to the identified acoustic pattern.

19. The system of claim 18, wherein the best frequency of a neural unit is a frequency for pure tone stimulation that needs a lowest sound level to evoke a neural response in the corresponding unit.

20. The system of claim 16, wherein each neural unit is an identifiable and stable single unit in at least one of the inferior colliculus, cochlear nucleus, auditory nerve, brainstem, and midbrain of the normal hearing animal.

21. The system of claim 16, wherein the neural responses of neural units of the normal hearing animal are acquired from neural recordings in the neural units when each acoustical pattern is played to the normal hearing animal at a plurality of frequencies.

22. The system of claim 21, wherein the neural response of each neural unit of the normal hearing animal comprises a train of action potentials generated in the neural unit of the normal hearing animal in response to the receipt of the acoustical pattern.

23. The system of claim 22, wherein the selected one or more neural units of the patient are stimulated with electrical pulses that are coincident with the trains of action potentials generated in the corresponding neural units of the normal hearing animal in response to the receipt of the acoustical pattern.

24. The system of claim 16, wherein the acoustical pattern is a segment or a frame of the acoustical signal.

25. The system of claim 24, wherein the acoustical pattern comprises a phoneme, a syllable, a word, words, or a combination thereof.

26. The system of claim 16, wherein the sensory device comprises one or more microphones.

27. The system of claim 16, wherein the electrodes of the cochlear implant comprise an electrode array with multiple electrode contacts.

28. The system of claim 16, wherein the processing device is in communication with the neural code library and the analyzer via a wired or cable connection, or a wireless connection.

29. The system of claim 16, wherein the transmitting device is in communication with the processing device and the cochlear implant via a wired or cable connection, or a wireless connection.

30. The system of claim 29, wherein the transmitting device is a wireless transmitting device.

31. The system of claim 30, wherein the wireless transmitting device is a Bluetooth wireless transmitter.

32. A method for playing an acoustical signal to a patient having a cochlear implant implanted, comprising:

(a) selecting an acoustical signal which the patient wants to listen to;

(b) looking up, by a processing device, a neural code library, wherein the neural code library comprises a plurality of digital representations of neural responses of neural units of at least one normal hearing animal, wherein each of the plurality of digital representations of neural responses corresponds to one of a plurality of digital representations of acoustic signals and comprises a neural response pattern;

(c) when the selected acoustical signal exists in the neural code library, selecting, by the processing device, one or more neural units of the patient to be stimulated by the cochlear implant implanted in the patient; and

(d) stimulating, by a transmitting device in communication with the processing device and the cochlear implant, the selected one or more neural units of the patient for listening to the acoustical signal.

33. The method of claim 32, wherein each neural unit is an identifiable and stable single unit in at least one of the inferior colliculus, cochlear nucleus, auditory nerve, brainstem, and midbrain of the normal hearing animal.

34. The method of claim 32, wherein the neural responses of neural units of the normal hearing animal are acquired from neural recordings in the neural units when each acoustical signal is played to the normal hearing animal at a plurality of frequencies.

35. The method of claim 34, wherein each neural response pattern comprises a train of action potentials generated in a corresponding neural unit of the normal hearing animal in response to the receipt of the acoustical signal.

36. The method of claim 32, wherein the selected one or more neural units of the patient are stimulated with electrical pulses that are coincident with the trains of action potentials generated in the corresponding neural units of the normal hearing animal in response to the receipt of the acoustical signal.

37. The method of claim 36, further comprising optimizing the selection of the units for stimulation optimization based on feedback from the patient.

38. A system for playing an acoustic signal to a patient having a cochlear implant implanted comprising:

(a) a neural code library comprising a plurality of digital representations of neural responses of neural units of at least one normal hearing animal, wherein each of the plurality of digital representations of neural responses corresponds to one of a plurality of digital representations of acoustic patterns and comprises a neural response pattern;

(d) a processing device in communication with the neural code library, configured to look up the neural code library, and when the selected acoustical signal exists in the neural code library, select one or more neural units of the patient to be stimulated by the cochlear implant implanted in the patient; and

(e) a transmitting device in communication with the processing device and the cochlear implant, configured to stimulate the selected one or more neural units of the patient for listening to the acoustical signal.

39. The system of claim 38, wherein each neural unit is an identifiable and stable single unit in at least one of the inferior colliculus, cochlear nucleus, auditory nerve, brainstem, and midbrain of the normal hearing animal.

40. The system of claim 39, wherein the neural responses of neural units of the normal hearing animal are acquired from neural recordings in the neural units when each acoustical pattern is played to the normal hearing animal at a plurality of frequencies.

41. The system of claim 40, wherein each neural response pattern comprises a train of action potentials generated in a corresponding neural unit of the normal hearing animal in response to the receipt of the acoustical signal.

42. The system of claim 41, wherein the selected one or more neural units of the patient are stimulated with electrical pulses that are coincident with the train of action potentials generated in the neural unit of the normal hearing animal in response to the receipt of the acoustical signal.

43. The system of claim 38, wherein electrodes of the cochlear implant comprise an electrode array with multiple electrode contacts.

44. The system of claim 38, wherein the processing device is in communication with the neural code library via a wired or cable connection, or a wireless connection.

45. The system of claim 38, wherein the transmitting device is in communication with the processing device and the cochlear implant via a wired or cable connection, or a wireless connection.

46. The system of claim 45, wherein the transmitting device is a wireless transmitting device.

47. The system of claim 46, wherein the wireless transmitting device is a Bluetooth wireless transmitter.