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Microfluidic device for cell separation and uses thereof

  • US 10,081,014 B2
  • Filed: 11/18/2016
  • Issued: 09/25/2018
  • Est. Priority Date: 09/27/2002
  • Status: Expired due to Term
First Claim
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1. A device for separating fetal blood cells from a liquid sample, comprising:

  • a substrate;

    a flow chamber having an inlet and an outlet arranged on the substrate; and

    a plurality of obstacles arranged in an array within the flow chamber on the substrate, wherein obstacles in a first region of the flow chamber are coupled to one or more first binding moieties that selectively bind to a first type of blood cell and wherein obstacles in a second region of the flow chamber are coupled to one or more second binding moieties that selectively bind to a second type of blood cell comprising fetal blood cells when a liquid sample comprising fetal blood cells is flowed through the flow chamber.

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