Spraying system and methods of use thereof
First Claim
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1. A method of disposing a layer of a matrix on a sample, comprising:
- providing at least one sample;
providing a spraying system comprising;
a liquid system for providing a liquid to a nebulizer;
a gas system for providing a gas to the nebulizer, wherein the nebulizer is configured to produce a nebulized liquid;
a control system for controlling the introduction of the liquid, the gas, or the liquid and gas, to the nebulizer; and
a sample system, wherein the sample system includes an area for the at least one sample to be disposed,wherein the nebulizer directs the liquid onto the area where the sample is to be disposed via a nozzle; and
disposing a layer of a matrix uniformly onto a portion of the at least one sample in about 2 to 30 seconds, wherein the layer of matrix is about 100 nm to 500 μ
m thick.
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Abstract
Embodiments of the present disclosure provide for spraying systems, methods of disposing a layer of matrix onto a sample, and the like.
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Citations
21 Claims
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1. A method of disposing a layer of a matrix on a sample, comprising:
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providing at least one sample; providing a spraying system comprising; a liquid system for providing a liquid to a nebulizer; a gas system for providing a gas to the nebulizer, wherein the nebulizer is configured to produce a nebulized liquid; a control system for controlling the introduction of the liquid, the gas, or the liquid and gas, to the nebulizer; and a sample system, wherein the sample system includes an area for the at least one sample to be disposed, wherein the nebulizer directs the liquid onto the area where the sample is to be disposed via a nozzle; and disposing a layer of a matrix uniformly onto a portion of the at least one sample in about 2 to 30 seconds, wherein the layer of matrix is about 100 nm to 500 μ
m thick. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of disposing a layer of a matrix on a sample, comprising:
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providing at least one sample; providing a spraying system comprising; a liquid system for providing a single liquid to a nebulizer, wherein the liquid system includes a liquid delivery system selected from the group consisting of;
a gravity liquid delivery system and a siphon liquid delivery system;a gas system for providing a gas to the nebulizer, wherein the nebulizer is configured to produce a nebulized liquid from the liquid from the liquid system; a control system for controlling introduction of the liquid, the gas, or the liquid and gas, to the nebulizer; and a sample system, wherein the sample system includes an area for the at least one sample to be disposed; wherein the nebulizer directs the nebulized liquid onto the area where the sample is to be disposed via a nozzle of the nebulizer; and wherein the nebulizer and the area where the at least one sample is to be disposed are disposed in a chamber; and disposing a layer of a matrix uniformly onto a portion of the at least one sample in about 2 to 30 seconds, wherein the layer of matrix is about 100 nm to 500 μ
m thick. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification