Compounds for inducing proliferation and differentiation of cells, and methods of use thereof
First Claim
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1. A method of inducing differentiation of one or more induced pluripotent stem cell (iPS cell)-derived, immature hepatocyte cells (iHep cells), the method comprising:
- contacting the one or more iHep cells with compound 105 (N,N′
-(methylenebis(4,1-phenylene))diacetamide);
or a pharmaceutically acceptable salt thereof;
wherein said contacting with the compound induces differentiation of the one or more immature iHep cells into mature hepatocytes.
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Abstract
The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention. Liver disease affects more than 500 million people worldwide. Organ transplantation is the gold standard for treatment of liver failure, but organ shortages are acute.
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8 Claims
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1. A method of inducing differentiation of one or more induced pluripotent stem cell (iPS cell)-derived, immature hepatocyte cells (iHep cells), the method comprising:
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contacting the one or more iHep cells with compound 105 (N,N′
-(methylenebis(4,1-phenylene))diacetamide);
or a pharmaceutically acceptable salt thereof;wherein said contacting with the compound induces differentiation of the one or more immature iHep cells into mature hepatocytes. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of inducing differentiation of one or more induced pluripotent stem cell (iPS cell)-derived endothelial cells, the method comprising contacting the one or more iPS cell-derived endothelial cells with compound 105 (N,N′
- -(methylenebis(4,1-phenylene)) diacetamide), or a pharmaceutically acceptable salt thereof,
wherein said contacting with the compound induces differentiation of the one or more iPS cell-derived endothelial cells to produce a population of more mature nitric oxide-producing endothelial cells. - View Dependent Claims (8)
- -(methylenebis(4,1-phenylene)) diacetamide), or a pharmaceutically acceptable salt thereof,
Specification