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Vertical wheel bioreactors

  • US 10,081,787 B2
  • Filed: 09/26/2016
  • Issued: 09/25/2018
  • Est. Priority Date: 10/26/2005
  • Status: Active Grant
First Claim
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1. A system for performing a cell culture growth process, comprising:

  • a containment vessel for holding a cell culture medium, the containment vessel comprising a generally semi-cylindrical bottom wall defining a semi-cylindrical concavity therewithin, the containment vessel having a rotatable mixing wheel mounted within for rotation about a horizontal axis approximately coincident with an axis of curvature of the semi-cylindrical bottom wall, the mixing wheel having a rotational diameter that extends into close proximity with the semi-cylindrical bottom wall; and

    an impeller defined within an outer rim on the mixing wheel configured to generate axial flow of at least a portion of the contents of the containment vessel upon rotation of the mixing wheel,wherein the containment vessel may be enclosed and sterilized so that a cell culture medium and nutrients may be provided within the containment vessel to support growth of a cell culture within the cell culture medium while rotating the mixing wheel about the horizontal axis to mix the contents of the containment vessel.

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