Anchorage devices comprising an active pharmaceutical ingredient
First Claim
1. A device comprising a non-porous first sheet and a second sheet including a mesh substrate, said sheets being joined to define a pocket, said mesh substrate first being coated with a polymer comprising at least one active pharmaceutical ingredient and then being coated with a hemostatic agent, said mesh substrate comprising a matrix of filaments, said filaments defining pores therebetween, said pores ranging in size between about 5 mm and about 10 mm, said mesh substrate comprising an aperture having a size that is larger than that of the pores, wherein a shunt is positioned in said pocket.
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Abstract
An anchorage device comprising a mesh substrate coupled to an implantable medical device is disclosed, where the mesh substrate has a coating comprising a polymer, and the mesh further comprises at least one active pharmaceutical ingredient. The active pharmaceutical agent is designed to elute from the mesh over time. The mesh substrate can be configured to reduce the mass of the anchorage device such that tissue in-growth and/or scar tissue formation at the treatment site is reduced. In some embodiments, the mesh substrate can be formed with a mesh having a low areal density. In some embodiments, the mesh substrate can include one or more apertures or pores to reduce the mass of the substrate.
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Citations
26 Claims
- 1. A device comprising a non-porous first sheet and a second sheet including a mesh substrate, said sheets being joined to define a pocket, said mesh substrate first being coated with a polymer comprising at least one active pharmaceutical ingredient and then being coated with a hemostatic agent, said mesh substrate comprising a matrix of filaments, said filaments defining pores therebetween, said pores ranging in size between about 5 mm and about 10 mm, said mesh substrate comprising an aperture having a size that is larger than that of the pores, wherein a shunt is positioned in said pocket.
- 16. A device comprising a non-porous first sheet and a second sheet including a mesh substrate, said mesh substrate having a coating comprising a first layer that is applied directly to said mesh substrate and a second layer that is applied directly to said first layer, said first layer comprising a polymer and at least one active pharmaceutical ingredient, said second layer comprising a hemostatic agent, said mesh substrate comprising a matrix of filaments, said filaments defining pores therebetween, said pores ranging in size between about 5 mm and about 10 mm, said mesh substrate comprising an aperture having a size that is larger than that of the pores, wherein shunt is positioned between said sheets.
- 20. An anchorage device comprising a non-porous first sheet and a second sheet including a mesh substrate, the sheets being joined along portions of perimeters of the sheets to define a pocket, the mesh substrate being coated with a coating comprising a first layer that is applied directly to the mesh substrate and a second layer that is applied directly to the first layer, the first layer comprising a biodegradable polymer and an active pharmaceutical ingredient, the polymer being configured to release the active pharmaceutical ingredient over time as the polymer degrades, the second layer comprising a hemostatic agent, wherein a shunt is positioned in said pocket.
Specification