Drug delivery apparatus

• US 10,086,187 B2
• Filed: 02/07/2013
• Issued: 10/02/2018
• Est. Priority Date: 02/07/2012
• Status: Active Grant

• Current Assignee: Renishaw PLC
• Original Assignee: Renishaw PLC
• Inventors: Woolley, Maxwell Roy, McMurtry, David Roberts, Gill, Steven Streatfield
• Primary Examiner(s): Bosworth, Kami A
• Application Number:
  US14/374,362
• Publication Number:
  US 20140371679A1
• Time in Patent Office: 2,063 Days
• CPC Class Codes: A61B 17/3403 Needle locating or guiding means guides for suture needles A61B17/0482; guiding or tracking by nuclear magnetic resonance G01R33/285
• CPC Class Codes: A61M 2039/0081 Means for facilitating introduction of a needle in the septum, e.g. guides, special construction of septum
• CPC Class Codes: A61M 2039/009 Means for limiting access to the septum, e.g. shields, grids
• CPC Class Codes: A61M 2039/0205 for injecting media
• CPC Class Codes: A61M 2039/025 through bones or teeth, e.g. through the skull
• CPC Class Codes: A61M 2039/0261 Means for anchoring port to the body, or ports having a special shape or being made of a specific material to allow easy implantation/integration in the body
• CPC Class Codes: A61M 2039/0264 with multiple inlets or multiple outlets
• CPC Class Codes: A61M 2039/027 having a particular valve, seal or septum septum A61M2039/0036
• CPC Class Codes: A61M 2039/0276 for introducing or removing fluids into or out of the body
• CPC Class Codes: A61M 2039/0282 with implanted tubes connected to the port
• CPC Class Codes: A61M 2039/0288 protectors, caps or covers therefor
• CPC Class Codes: A61M 2039/042 Shrouds encircling the access needle preventing accidental needle-stick
• CPC Class Codes: A61M 2039/1033 Swivel nut connectors, e.g. threaded connectors, bayonet-connectors
• CPC Class Codes: A61M 2039/1044 Verifying the connection, e.g. audible feedback, tactile feedback, visual feedback, using external light sources
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 39/0247 Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body peritoneal dialysis catheters A61M1/285; tracheostomy devices A61M16/0465; measuring pressure within the body A61B5/03; colostomy devices A61F5/445; gastrotomy feeding tubes A61J15/0015; means for fixing a feeding tube outside of the body A61J15/0053
• CPC Class Codes: A61M 39/04 having pierceable self-sealing members
• CPC Class Codes: A61M 39/10 Tube connectors; Tube couplings A61M39/02 takes precedence; connecting needles to syringes or hubs A61M5/34; connecting catheter tubes to hubs A61M25/0014
• CPC Class Codes: A61M 39/1011 Locking means for securing connection; Additional tamper safeties A61M39/16 takes precedence
• CPC Class Codes: A61M 39/105 Multi-channel connectors or couplings, e.g. for connecting multi-lumen tubes multi-channel connectors in general F16L37/56

Abstract

Percutaneous access apparatus is described that includes a percutaneous fluid access device having an extracorporeal portion, one or more ports accessible from the extracorporeal portion and a septum for sealing each port. A connector device having one or more hollow needles is attachable to the percutaneous fluid access device. The apparatus also includes an attachment mechanism for attaching the connector device to the extracorporeal portion and an actuation mechanism that, after the connector device has been attached to the extracorporeal portion, can be used to drive the one or more hollow needles through the septum to establish fluid communication between the one or more hollow needles and the one or more ports. The apparatus may be used for neurosurgery applications.

Claims

1. A percutaneous access apparatus comprising:

a percutaneous fluid access device comprising an extracorporeal portion, one or more ports accessible from the extracorporeal portion and a septum for sealing each port, and

a connector device comprising a body and a needle holder holding one or more hollow needles, the needle holder being moveable within the body,

wherein the apparatus includes an attachment mechanism for attaching the connector device to the extracorporeal portion, and an actuation mechanism that, after the connector device has been attached to the extracorporeal portion, can be used to move the needle holder within the body to thereby drive the one or more hollow needles through the septum to establish fluid communication between the one or more hollow needles and the one or more ports.

2. An apparatus according to claim 1, wherein the attachment mechanism comprises a first set of features on the extracorporeal portion and a second set of features on the connector device, wherein the first and second sets of features provide, when engaged, accurate alignment of the connector device with the extracorporeal portion.

3. An apparatus according to claim 1, wherein the attachment mechanism provides a kinematic, or pseudo-kinematic, connection between the extracorporeal portion and the connector device.

4. An apparatus according to claim 1, wherein the one or more hollow needles comprise a plurality of hollow needles and the one or more ports comprise a plurality of ports, wherein the attachment mechanism allows repeatable alignment of each hollow needle with a predetermined respective one of the ports.

5. An apparatus according to claim 1, wherein the attachment mechanism comprises a locking device for releasably locking the connector device to the extracorporeal portion, the connector device comprising the locking device.

6. An apparatus according to claim 5, wherein the locking device comprises a screw and a hinged engagement member, wherein tightening the screw forces the hinged engagement member into contact with the extracorporeal portion thereby locking the connector device to the extracorporeal portion.

7. An apparatus according to claim 1, wherein the needle holder is retained within an axial alignment channel formed within the connector device.

8. An apparatus according to claim 7, wherein the actuation mechanism can be actuated to drive the needle holder back and forth along the alignment channel.

9. An apparatus according to claim 8, wherein the actuation mechanism comprises a threaded shaft and a rotatable knurled hub having a threaded channel, the needle holder being attached to a distal end of the threaded shaft and the threaded shaft being retained in the threaded channel of the rotatable knurled hub, wherein rotation of the knurled hub translates the needle holder back and forth along the alignment channel.

10. An apparatus according to claim 1, wherein the percutaneous fluid access device comprises a subcutaneous base portion through which the one or more ports extend, wherein the subcutaneous base portion comprises one or more port outlets for connection to one or more implanted catheters.

11. An apparatus according to claim 1, wherein the percutaneous fluid access device comprises a subcutaneous base portion, the subcutaneous base portion being at least partially insertable into a complementary recess formed in a bone, the subcutaneous base portion comprising one or more features for gripping an internal surface of the complementary recess thereby directly anchoring the subcutaneous base portion to the bone.

12. An apparatus according to claim 1, wherein the percutaneous fluid access device comprises printed titanium.

13. An apparatus according to claim 1, wherein the one or more ports comprise a plurality of ports and the septum is a single septum provided to cover each of the plurality of ports, wherein the single septum can be accessed and removed via the extracorporeal portion of the percutaneous fluid access device.

14. A connector device for attachment to a percutaneous fluid access device having one or more ports and a septum for sealing each port, the connector device comprising:

a body and a needle holder holding one or more hollow needles, the needle holder comprising a threaded shaft and being moveable within the body,

an attachment mechanism for attaching the body of the connector device to an extracorporeal portion of the associated percutaneous fluid access device, and

an actuation mechanism comprising an internally threaded portion that engages the threaded shaft and drives the one or more hollow needles towards the septum of the associated percutaneous fluid access device when the threaded portion is rotated to thereby provide fluid communication between the one or more hollow needles and the one or more ports of the associated percutaneous fluid access device.

15. A connector device according to claim 14, wherein the needle holder surrounds at least a portion of an outer surface of at least one of the one or more hollow needles.