Therapeutic window determination
First Claim
1. A method comprising:
- determining, by a processor, an efficacy threshold value of at least one electrical stimulation parameter, wherein the efficacy threshold value is determined based on a volume of tissue activation expected to result from delivery of electrical stimulation by an electrode to a patient;
determining, by the processor, that an adverse-effects threshold value of the at least one electrical stimulation parameter is unknown; and
selecting, by the processor and in response to determining that the adverse-effects threshold value of the at least one stimulation parameter is unknown, a predetermined adverse-effects threshold value of the at least one stimulation parameter.
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Accused Products
Abstract
A therapeutic window for at least one electrode of a medical system may be determined based on a volume of tissue expected to be activated (“VTA”) by electrical stimulation delivered by the at least one electrode. In some examples, a processor determines the therapeutic window for a particular electrode by at least determining an efficacy threshold based on the VTA expected to result from the delivery of electrical stimulation according to a set of electrical stimulation parameter values including the stimulation parameter at the efficacy threshold, and determining an adverse-effects threshold based on the VTA expected to result from the delivery of electrical stimulation according to a set of electrical stimulation parameter values including the stimulation parameter at the adverse-effects threshold.
46 Citations
36 Claims
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1. A method comprising:
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determining, by a processor, an efficacy threshold value of at least one electrical stimulation parameter, wherein the efficacy threshold value is determined based on a volume of tissue activation expected to result from delivery of electrical stimulation by an electrode to a patient; determining, by the processor, that an adverse-effects threshold value of the at least one electrical stimulation parameter is unknown; and selecting, by the processor and in response to determining that the adverse-effects threshold value of the at least one stimulation parameter is unknown, a predetermined adverse-effects threshold value of the at least one stimulation parameter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A system comprising:
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a memory; and a processor configured to; determine an efficacy threshold value of at least one electrical stimulation parameter, wherein the efficacy threshold value is determined based on a volume of tissue activation expected to result from delivery of electrical stimulation by an electrode to a patient, determine that an adverse-effects threshold value of the at least one electrical stimulation parameter is unknown, and select, from the memory and in response to determining that the adverse-effects threshold value of the at least one stimulation parameter is unknown, a predetermined adverse-effects threshold value of the at least one stimulation parameter. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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17. A system comprising:
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means for determining an efficacy threshold value of at least one electrical stimulation parameter, wherein the means for determining the efficacy threshold value is configured to determine the efficacy threshold value based on a volume of tissue activation expected to result from delivery of electrical stimulation by an electrode to a patient; means for determining that an adverse-effects threshold value of the at least one electrical stimulation parameter is unknown; and means for selecting, in response to a determination that the adverse-effects threshold value of the at least one stimulation parameter is unknown, a predetermined adverse-effects threshold value of the at least one stimulation parameter. - View Dependent Claims (18)
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19. A non-transitory computer-readable medium comprising instructions that, when executed by a processor, cause the processor to:
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determine an efficacy threshold value of at least one electrical stimulation parameter, wherein the instructions cause the processor to determine the efficacy threshold value based on a volume of tissue activation expected to result from delivery of electrical stimulation by an electrode to a patient; determine that an adverse-effects threshold value of the at least one electrical stimulation parameter is unknown; and select, in response to determining that the adverse-effects threshold value of the at least one stimulation parameter is unknown, a predetermined adverse-effects threshold value of the at least one stimulation parameter. - View Dependent Claims (20)
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21. A method comprising:
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determining, by a processor, that an efficacy threshold value of at least one electrical stimulation parameter is unknown; determining, by the processor, an adverse-effects threshold value of the at least one electrical stimulation parameter, wherein the adverse-effects threshold value is determined based on a volume of tissue activation expected to result from delivery of electrical stimulation by an electrode to a patient; and determining, by the processor, a therapeutic window of the at least one electrical stimulation parameter for the electrode based on the adverse-effects threshold value and the determination that the efficacy threshold value is unknown. - View Dependent Claims (22, 23, 24, 25)
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26. A system comprising:
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a memory; and a processor configured to; determine that an efficacy threshold value of at least one electrical stimulation parameter is unknown, determine an adverse-effects threshold value of the at least one electrical stimulation parameter, wherein the adverse-effects threshold value is determined based on a volume of tissue activation expected to result from delivery of electrical stimulation by an electrode to a patient, determine a therapeutic window of the at least one electrical stimulation parameter for the electrode based on the adverse-effects threshold value and the determination that the efficacy threshold value is unknown; and store the therapeutic window in the memory. - View Dependent Claims (27, 28, 29, 30)
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31. A method comprising:
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determining, by a processor, an efficacy threshold value of at least one electrical stimulation parameter, wherein the efficacy threshold value is determined based on a first volume of tissue activation expected to result from delivery of electrical stimulation by an electrode to a patient; determining, by the processor, an adverse-effects threshold value of the at least one electrical stimulation parameter, wherein the adverse-effects threshold value is determined based on a second volume of tissue activation expected to result from delivery of electrical stimulation to the patient; determining, by the processor, that the efficacy threshold value is not less than or equal to the adverse-effects threshold value; determining, by the processor and based on determining that the efficacy threshold value is not less than or equal to the adverse-effects threshold value, a therapeutic window of the at least one electrical stimulation parameter for the electrode is zero; and storing the therapeutic window with an indication of the electrode in a memory. - View Dependent Claims (32, 33)
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34. A system comprising:
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a memory; and a processor configured to; determine an efficacy threshold value of at least one electrical stimulation parameter, wherein the efficacy threshold value is determined based on a first volume of tissue activation expected to result from delivery of electrical stimulation by an electrode to a patient, determine an adverse-effects threshold value of the at least one electrical stimulation parameter, wherein the adverse-effects threshold value is determined based on a second volume of tissue activation expected to result from delivery of electrical stimulation to the patient, determine that the efficacy threshold value is not less than or equal to the adverse-effects threshold value, determine, based on determining that the efficacy threshold value is not less than or equal to the adverse-effects threshold value, a therapeutic window of the at least one electrical stimulation parameter for the electrode is zero, and store the therapeutic window with an indication of the electrode in the memory. - View Dependent Claims (35, 36)
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Specification