Tissue-penetrating electrochemical sensor featuring a co-electrodeposited thin film comprised of polymer and bio-recognition element
First Claim
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1. A tissue-penetrating electrochemical sensor device for the quantification of a chemical or biochemical entity in a physiological fluid, the device comprising:
- a tissue-penetrating electrochemical sensor comprising at least one spatially-defined working electrode;
a conducting polymer film comprising an organic electroactive monomer precursor and at least one biorecognition element, the organic electroactive monomer precursor and the at least one biorecognition element dispersed uniformly and physically entrapped in the conducting polymer film;
wherein the conducting polymer film is produced by immersing the tissue-penetrating electrochemical sensor in a solution containing the at least one biomolecular recognition element and the organic electroactive monomer precursor which is dissolved in the solution, and wherein application of an oxidizing potential or a reducing potential at the spatially-defined working electrode causes the co-electrodeposition of the conducting polymer film.
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Abstract
A method and device to impart the ability to selectively quantify chemical/biochemical analytes occupying physiological fluids via an automated process that allow the precise and spatially-defined simultaneous deposition of a thin-film of polymer containing an immobilized biorecognition element dispersed therein. A tissue penetrating electrochemical sensor comprises at least one working electrode and at least one of a reference electrode and a counter electrode.
109 Citations
20 Claims
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1. A tissue-penetrating electrochemical sensor device for the quantification of a chemical or biochemical entity in a physiological fluid, the device comprising:
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a tissue-penetrating electrochemical sensor comprising at least one spatially-defined working electrode; a conducting polymer film comprising an organic electroactive monomer precursor and at least one biorecognition element, the organic electroactive monomer precursor and the at least one biorecognition element dispersed uniformly and physically entrapped in the conducting polymer film; wherein the conducting polymer film is produced by immersing the tissue-penetrating electrochemical sensor in a solution containing the at least one biomolecular recognition element and the organic electroactive monomer precursor which is dissolved in the solution, and wherein application of an oxidizing potential or a reducing potential at the spatially-defined working electrode causes the co-electrodeposition of the conducting polymer film. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for the fabrication of a tissue-penetrating electrochemical sensor for the quantification of a chemical or biochemical entity in a physiological fluid, the method comprising:
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immersing a tissue-penetrating electrochemical sensor comprising at least one spatially-defined working electrode in a solution comprising at least one biomolecular recognition element and an organic electroactive monomer precursor dissolved in the solution; applying of an oxidizing potential or a reducing potential at the spatially-defined working electrode, causing a co-electrodeposition of a polymer film from the organic electroactive monomer precursor and the at least one biorecognition element dispersed uniformly and physically entrapped in the polymer film. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification