Minimally-invasive tissue ablation using high contrast electric fields

• US 10,092,351 B2
• Filed: 02/11/2015
• Issued: 10/09/2018
• Est. Priority Date: 02/11/2015
• Status: Active Grant

• Current Assignee: Elwha LLC (Intellectual Ventures LLC)
• Original Assignee: Elwha LLC (Intellectual Ventures LLC)
• Inventors: Urzhumov, Yaroslav A.
• Primary Examiner(s): FOWLER, DANIEL WAYNE
• Application Number:
  US14/619,393
• Publication Number:
  US 20160228183A1
• Time in Patent Office: 1,336 Days
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00732 Frequency

Abstract

Described embodiments include a system and a method. A system includes an electromagnetic structure having a surface and a radiofrequency electromagnetic field source. The field source includes electronically controllable, artificially structured electromagnetic unit cells configured to create quasi-static electromagnetic fields within the electromagnetic structure. Each unit cell is responsive to a control signal. A selector circuit selects a quasi-static electromagnetic field pattern creating a high contrast electric field in a subwavelength electromagnetic cavity and is defined by the surface of the electromagnetic structure and an exterior surface of a perturbing object. The high contrast electric field has a power density that is localized to a volume adjoining the exterior surface of the perturbing object. A field pattern implementation circuit generates the control signal assigning electromagnetic field characteristic to each of the electromagnetic unit cells. The assigned radiofrequency electromagnetic field characteristics collectively creating the selected quasi-static electromagnetic field pattern.

Claims

1. A system comprising:

a perturbing object configured to be implanted within or proximate to a target tissue of a living vertebrate subject;

an electromagnetic structure having a surface that includes a radiofrequency electromagnetic field source;

the radiofrequency electromagnetic field source including at least two electronically controllable, artificially structured electromagnetic unit cells configured to create quasi-static radiofrequency electromagnetic fields, each unit cell respectively responsive to a control signal;

a selector circuit configured to select a quasi-static electromagnetic field pattern creating a radiofrequency electric field in a subwavelength electromagnetic cavity defined at least in part by the surface of the electromagnetic structure and an exterior surface of the perturbing object, the radiofrequency electric field including a power density localized to a volume adjoining the exterior surface of the perturbing object; and

a field pattern implementation circuit configured to;

generate the control signal to which each unit cell is respectively responsive, the control signal assigning a respective radiofrequency electromagnetic field characteristic to each of the at least two electronically controllable, artificially structured electromagnetic unit cells; and

transmit the control signal to the at least two electronically controllable, artificially structured electromagnetic unit cells, the respective assigned radiofrequency electromagnetic field characteristics collectively causing the at least two electronically controllable, artificially structured electromagnetic unit cells to create the selected quasi-static radiofrequency electromagnetic field pattern within the subwavelength electromagnetic cavity.

2. The system of claim 1, wherein the electromagnetic structure includes a subwavelength electromagnetic cavity structure.

3. The system of claim 1, wherein the electromagnetic structure substantially or partially confines electromagnetic energy within a frequency band.

4. The system of claim 1, wherein the electromagnetic structure is dimensioned to at least partially surround part of an adult human.

5. The system of claim 1, wherein the at least two electronically controllable, artificially structured electromagnetic unit cells are configured and dimensioned to create quasi-static radiofrequency electromagnetic fields converging on the perturbing object such that the at least two electronically controllable, artificially structured electromagnetic cells define a total view angle approaching 4π

steradian from the point of view of the perturbing object.

6. The system of claim 1, wherein the perturbing object is not physically connected to any exterior part of the system by any conducting path.

7. The system of claim 1, wherein the electromagnetic structure supports at least two quasi-static radiofrequency electromagnetic field patterns.

8. The system of claim 1, wherein the electromagnetic structure includes a parallel plate electromagnetic structure having a first surface portion and a parallel second surface portion facing the first surface portion.

9. The system of claim 1, wherein the surface includes an arcuate shape.

10. The system of claim 1, wherein the surface includes a spherical shape.

11. The system of claim 1, wherein a first portion of the surface includes the radiofrequency electromagnetic field source and a second portion of the surface includes a passive surface.

12. The system of claim 1, wherein the radiofrequency electromagnetic field source is configured to generate a near-field region electromagnetic field in a portion of the 100 MHz-300 MHz range.

13. The system of claim 1, wherein the radiofrequency electromagnetic field source is configured to generate a tunable near-field region quasi-static electromagnetic field.

14. The system of claim 1, wherein the radiofrequency electromagnetic field source includes at least two spaced apart, electronically controllable, artificially structured electromagnetic unit cells.

15. The system of claim 1, wherein each artificially structured electromagnetic unit cell of the at least two artificially structured electromagnetic unit cells is configured to transform received radiofrequency electromagnetic waves into a radiofrequency electromagnetic field within at least a portion of the electromagnetic cavity structure.

16. The system of claim 1, wherein each artificially structured electromagnetic unit cell of the at least two artificially structured electromagnetic unit cells includes a respective controller configured to regulate electromagnetic fields generated by the respective electromagnetic unit cell in response to the control signal.

17. The system of claim 1, wherein the radiofrequency electromagnetic field source includes at least two groups of at least two electronically controllable, artificially structured electromagnetic unit cells.

18. The system of claim 1, wherein the at least two artificially structured electromagnetic unit cells includes at least two metamaterial unit cells.

19. The system of claim 1, wherein the at least two artificially structured electromagnetic unit cells are each configured to generate a magnetic field-dominant radiofrequency near-field with magnetic (B) and electric (E) field intensities such that (B×

c)/E>

1 (where “

c”

is the speed of light).

20. The system of claim 1, wherein the selector circuit is configured to select an optimized quasi-static electromagnetic field based on a maximization of a temperature increase in a selected volume of tissue adjoining the perturbing object implanted in a vertebrate subject resulting from exposure to electromagnetic fields, subject to a constraint that the temperature elsewhere in the vertebrate subject does not exceed a safe limit.

21. The system of claim 1, wherein the selector circuit is configured to select the quasi-static electromagnetic field pattern responsive to real-time data received from a radiofrequency electromagnetic field sensor indicative of a radiofrequency electromagnetic field in a tissue of a vertebrate subject in which the perturbing object is implanted.

22. The system of claim 1, wherein the selector circuit is configured to select the quasi-static electromagnetic field pattern responsive to real-time data received from a temperature sensor.

23. The system of claim 1, wherein the selector circuit is configured to select the quasi-static electromagnetic field pattern responsive to (i) a parameter of the subwavelength electromagnetic cavity, and (ii) a parameter of the perturbing object.

24. The system of claim 1, wherein the selector circuit is configured to select a quasi-static electromagnetic field pattern producing an evanescent coupling between a wave associated with the surface of the electromagnetic structure and a wave associated with the perturbing object.

25. The system of claim 1, wherein the selector circuit is configured to select the quasi-static electromagnetic field pattern in response to a model-based quasi-static electromagnetic field interaction between the surface of the electromagnetic structure and the exterior surface of the perturbing object.

26. The system of claim 25, wherein the model-based estimation is selected from a best available quasi-static electromagnetic field pattern from at least two available quasi-static electromagnetic field patterns.

27. The system of claim 1, wherein the selector circuit is configured to select the quasi-static electromagnetic field pattern from a library of at least two quasi-static electromagnetic field patterns creating a high contrast radiofrequency electric field having a power density localized to a volume adjoining the exterior surface of the perturbing object.

28. The system of claim 1, wherein the power density of the selected high contrast radiofrequency electric field includes a first average power density of the radiofrequency electric field in a first volume within 5 mm of the perturbing object that is at least two times greater than a second average power density of the radiofrequency electric field in a second volume between 5 mm and 10 mm of the perturbing object.

29. The system of claim 1, wherein the power density of the selected high contrast radiofrequency electric field includes a first specific absorption rate (SAR) of the radiofrequency electric field in a first volume within 5 mm of the perturbing object that is at least 2 times greater than a second SAR of the radiofrequency electric field in a second volume between 5 mm and 10 mm of the perturbing object.

30. The system of claim 1, wherein the selector circuit is configured to select a quasi-static electromagnetic field pattern creating a radiofrequency electric field in the subwavelength electromagnetic cavity corresponding to an eigenmode of the subwavelength electromagnetic cavity.

31. The system of claim 1, wherein the electromagnetic cavity constitute a three-dimensional topological manifold with a non-connected boundary.

32. The system of claim 31, wherein the selector circuit is configured to select the quasi-static electromagnetic field responsive to (i) a parameter of the manifold with non-connected boundary and (ii) a parameter of the perturbing object.

33. The system of claim 1, wherein the power density localized to a volume adjoining the exterior surface of the perturbing object includes a power density directly heating tissue of a living vertebrate adjoining the exterior surface of the perturbing object to a cell damage temperature.

34. The system of claim 1, wherein the selector circuit is configured to receive data indicative of a change in a spatial relationship between the perturbing object and the surface, and in response to the received data, select another quasi-static electromagnetic field pattern creating a high contrast radiofrequency electric field having a power density localized to a volume adjoining an exterior surface of a perturbing object with the changed spatial relationship.

35. The system of claim 1, wherein the perturbing object includes a major dimension that is less than 1 mm.

36. The system of claim 1, wherein the perturbing object includes a perturbing object having a permittivity or permeability that does not naturally occur.

37. The system of claim 1, wherein the radiofrequency electromagnetic field source includes at least two groups of at least two electronically controllable, artificially structured electromagnetic unit cells, and the field pattern implementation circuit is configured to generate a control signal defining a radiofrequency electromagnetic field characteristic respectively assigned to each group of at least two groups of electronically controllable, artificially structured electromagnetic unit cells.

38. The system of claim 1, further comprising:

a radiofrequency electromagnetic wave conducting structure configured to distribute radiofrequency electromagnetic waves to the at least two artificially structured electromagnetic unit cells.

39. A system comprising:

a three-dimensional domain having a surface and a radiofrequency electromagnetic field source;

a perturbing object configured to be implanted within or proximate to a target tissue of a living vertebrate subject;

the radiofrequency electromagnetic field source including at least two electronically controllable electromagnetic unit cells configured to create quasi-static radiofrequency electromagnetic fields within the three-dimensional domain;

a selector circuit configured to select a quasi-static electromagnetic field pattern creating a radiofrequency electric field in an electromagnetic cavity defined at least in part by the surface of the three-dimensional domain and an exterior surface of the perturbing object, the radiofrequency electric field including a power density localized to a volume adjoining the exterior surface of the perturbing object; and

a field pattern implementation circuit configured to;

generate a control signal assigning a respective radiofrequency electromagnetic field characteristic to each of the at least two electronically controllable electromagnetic unit cells; and

transmit the control signal to the at least two electronically controllable electromagnetic unit cells, the respective assigned radiofrequency electromagnetic field characteristics collectively causing the at least two electronically controllable electromagnetic unit cells to create the selected quasi-static electromagnetic field pattern within the electromagnetic cavity.

40. The system of claim 39, wherein the electromagnetic cavity includes a subwavelength electromagnetic cavity.

41. A method comprising:

selecting a quasi-static electromagnetic field pattern creating a radiofrequency electric field in a subwavelength electromagnetic cavity, the radiofrequency electric field including a power density localized to a volume adjoining an exterior surface of a perturbing object implanted within or proximate to a target tissue of a living vertebrate subject, the subwavelength electromagnetic cavity defined at least in part by a surface of an electromagnetic structure and the exterior surface of the perturbing object;

assigning a respective radiofrequency electromagnetic field characteristic to each of at least two electronically controllable, artificially structured electromagnetic unit cells of a radiofrequency electromagnetic field source associated with the surface of the electromagnetic structure, the respective assigned radiofrequency electromagnetic field characteristics collectively creating the selected quasi-static electromagnetic field pattern within the electromagnetic cavity;

implementing the assigned respective radiofrequency electromagnetic field characteristic in each of the at least two electronically controllable, artificially structured electromagnetic unit cells; and

creating the selected quasi-static electromagnetic field pattern.

42. The method of claim 41, further comprising:

thermally ablating the volume of the target tissue of the living vertebrate adjoining the exterior surface of the implanted perturbing object.

43. The method of claim 41, further comprising:

positioning the implanted perturbing object within a near-field coupling region of the electromagnetic structure.