Treatment of diabetes mellitus by long-acting formulations of insulins
First Claim
1. A method of treating Type I or Type II Diabetes Mellitus in a patient comprising administering to the patient an aqueous pharmaceutical formulation, wherein the treatment reduces the risk of nocturnal hypoglycemia, wherein the aqueous pharmaceutical formulation comprises 200-1000 U/mL [equimolar to 200-1000 IU human insulin] of insulin glargine, with the proviso that the concentration of insulin glargine is not 684 U/mL, wherein the time interval between administrations is in the range of 20 hours to 23.5 hours or in the range of 24.5 hours to 28 hours on at least two days per week for the duration of treatment.
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Accused Products
Abstract
The application relates to an aqueous pharmaceutical formulation for use in the treatment of Type I or Type II Diabetes Mellitus, wherein the treatment reduces the risk of nocturnal hypoglycemia, said formulation comprising 200-1000 U/mL [equimolar to 200-1000 IU human insulin] of insulin glargine, with the proviso that the concentration of said formulation is not 684 U/mL of insulin glargine.
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Citations
35 Claims
- 1. A method of treating Type I or Type II Diabetes Mellitus in a patient comprising administering to the patient an aqueous pharmaceutical formulation, wherein the treatment reduces the risk of nocturnal hypoglycemia, wherein the aqueous pharmaceutical formulation comprises 200-1000 U/mL [equimolar to 200-1000 IU human insulin] of insulin glargine, with the proviso that the concentration of insulin glargine is not 684 U/mL, wherein the time interval between administrations is in the range of 20 hours to 23.5 hours or in the range of 24.5 hours to 28 hours on at least two days per week for the duration of treatment.
- 33. A method of treating Type I or Type II Diabetes Mellitus in a patient comprising administering to the patient an aqueous pharmaceutical formulation comprising 300 U/mL insulin glargine [equimolar to 300 IU human insulin], wherein the time interval between administrations is in the range of 20 hours to 23.5 hours or in the range of 24.5 hours to 28 hours on at least two days per week for the duration of treatment.
Specification