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Aerosol pirfenidone and pyridone analog compounds and uses thereof

  • US 10,092,552 B2
  • Filed: 01/31/2012
  • Issued: 10/09/2018
  • Est. Priority Date: 01/31/2011
  • Status: Active Grant
First Claim
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1. A method for clinically efficacious treatment of idiopathic pulmonary fibrosis in an adult human comprising:

  • delivering a therapeutically effective dose of pirfenidone compound to the lung of the adult human by inhalation of an aerosol formed by nebulization of an aqueous solution comprising water;

    pirfenidone, at a concentration from about 5.0 to about 19.0 mg/mL;

    a permeant ion concentration of between about 30 mM and about 300 mM, wherein the permeant ions are chloride ions, bromide ions, or a combination thereof;

    a citrate or phosphate buffer; and

    a taste masking agent at a concentration of between 0.1 and 2.0 mM, wherein a total daily dose of inhaled pirfenidone does not exceed 480 mg, and wherein the therapeutically effective dose treats idiopathic pulmonary fibrosis by reducing a decline in forced vital capacity (FVC) in the lung of the adult human.

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