Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan
First Claim
1. A method for treating a human being with dextromethorphan comprising administering once or twice daily for at least eight consecutive days a combination of dextromethorphan and bupropion to the human being, wherein the human being is an extensive metabolizer of dextromethorphan and in need of treatment with dextromethorphan, wherein the combination is administered in a dosage form, which provides an AUC0-12 of dextromethorphan of about 700 ng·
- hr/mL to about 1050 ng·
hr/mL for the human being after eight consecutive days of administering the dosage form comprising the combination, and wherein after eight consecutive days of administering the dosage form comprising the combination to the human being, the AUC0-12 of dextromethorphan is at least about 15 times the AUC0-12 of dextromethorphan that would be achieved by administering the same amount of dextromethorphan without bupropion for eight consecutive days.
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Accused Products
Abstract
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
222 Citations
29 Claims
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1. A method for treating a human being with dextromethorphan comprising administering once or twice daily for at least eight consecutive days a combination of dextromethorphan and bupropion to the human being, wherein the human being is an extensive metabolizer of dextromethorphan and in need of treatment with dextromethorphan, wherein the combination is administered in a dosage form, which provides an AUC0-12 of dextromethorphan of about 700 ng·
- hr/mL to about 1050 ng·
hr/mL for the human being after eight consecutive days of administering the dosage form comprising the combination, and wherein after eight consecutive days of administering the dosage form comprising the combination to the human being, the AUC0-12 of dextromethorphan is at least about 15 times the AUC0-12 of dextromethorphan that would be achieved by administering the same amount of dextromethorphan without bupropion for eight consecutive days. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
- hr/mL to about 1050 ng·
- 17. A method for treating a human being with dextromethorphan, comprising administering to the human being dextromethorphan in combination with bupropion once or twice daily for at least eight consecutive days, wherein the human being is an extensive metabolizer of dextromethorphan and in need of treatment with dextromethorphan, wherein dextromethorphan and bupropion are administered in a dosage form, which provides a Cmax of dextromethorphan of about 60 ng/mL to about 110 ng/mL for the human being after eight consecutive days of administering the dosage form, and wherein after eight consecutive days of administering the dosage form to the human being, the Cmax of dextromethorphan is at least about 15 times the Cmax of dextromethorphan that would be achieved by administering the same amount of dextromethorphan without bupropion for eight consecutive days.
Specification