Gastric and colonic formulations and methods for making and using them
First Claim
1. A composition comprising:
- (i) from about 1 to about 25 milligrams (mg) bisoxatin (or 2,2-bis(4-hydroxyphenyl)-2H-benzo[b][1,4]oxazin-3(4H)-one), or bisoxatin acetate,(ii) from about 1 to about 25 grams of erythritol, or (2R,3S)-butane-1,2,3,4-tetraol, or isomers, sugar or polyol substitute isoforms, and(iii) a pharmaceutically acceptable salt or salts, wherein the pharmaceutically acceptable salt or salts comprise from about 1 to about 40 grams of a pharmaceutically acceptable salt or pharmaceutically acceptable salts and comprise at least one sodium salt selected from the group of;
a monobasic sodium phosphate, dibasic sodium phosphate, and/or tribasic sodium phosphate, a sodium sulfate, a sodium chloride, a sodium gluconate, a sodium citrate and a sodium aspartate.
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Accused Products
Abstract
In alternative embodiments, the invention provides compositions, e.g., formulations, used for gastric, gastrointestinal and/or colonic treatments or lavage, e.g., orthostatic lavage, e.g., for inducing the purgation (e.g., cleansing) of a gastrointestinal (GI) tract, including a colon; and methods for making and using them. In alternative embodiments, compositions and methods of the invention are used for the amelioration, treatment and/or prevention of constipation, for the treatment of abdominal pain, particularly non-specific abdominal pain, and diarrhea, including diarrhea caused by a drug side effect, a psychological condition, a disease or a condition such as Crohn'"'"'s Disease, a poison, a toxin or an infection, e.g., a toxin-mediated traveler'"'"'s diarrhea. In alternative embodiments, the invention provides pharmaceuticals and products (articles) of manufacture for delivering these compositions and formulations to an individual, e.g., a human or an animal.
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Citations
51 Claims
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1. A composition comprising:
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(i) from about 1 to about 25 milligrams (mg) bisoxatin (or 2,2-bis(4-hydroxyphenyl)-2H-benzo[b][1,4]oxazin-3(4H)-one), or bisoxatin acetate, (ii) from about 1 to about 25 grams of erythritol, or (2R,3S)-butane-1,2,3,4-tetraol, or isomers, sugar or polyol substitute isoforms, and (iii) a pharmaceutically acceptable salt or salts, wherein the pharmaceutically acceptable salt or salts comprise from about 1 to about 40 grams of a pharmaceutically acceptable salt or pharmaceutically acceptable salts and comprise at least one sodium salt selected from the group of;
a monobasic sodium phosphate, dibasic sodium phosphate, and/or tribasic sodium phosphate, a sodium sulfate, a sodium chloride, a sodium gluconate, a sodium citrate and a sodium aspartate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
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Specification