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Gastric and colonic formulations and methods for making and using them

  • US 10,092,573 B2
  • Filed: 12/13/2011
  • Issued: 10/09/2018
  • Est. Priority Date: 12/13/2010
  • Status: Active Grant
First Claim
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1. A composition comprising:

  • (i) from about 1 to about 25 milligrams (mg) bisoxatin (or 2,2-bis(4-hydroxyphenyl)-2H-benzo[b][1,4]oxazin-3(4H)-one), or bisoxatin acetate,(ii) from about 1 to about 25 grams of erythritol, or (2R,3S)-butane-1,2,3,4-tetraol, or isomers, sugar or polyol substitute isoforms, and(iii) a pharmaceutically acceptable salt or salts, wherein the pharmaceutically acceptable salt or salts comprise from about 1 to about 40 grams of a pharmaceutically acceptable salt or pharmaceutically acceptable salts and comprise at least one sodium salt selected from the group of;

    a monobasic sodium phosphate, dibasic sodium phosphate, and/or tribasic sodium phosphate, a sodium sulfate, a sodium chloride, a sodium gluconate, a sodium citrate and a sodium aspartate.

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