Drug delivery device with drug container comprising a sensor and optical data transmission system

• US 10,092,697 B2
• Filed: 10/25/2013
• Issued: 10/09/2018
• Est. Priority Date: 10/29/2012
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Nessel, Christian, Auernhammer, Daniel
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): SWANSON, LEAH JENNINGS
• Application Number:
  US14/439,175
• Publication Number:
  US 20150273145A1
• Time in Patent Office: 1,810 Days
• CPC Class Codes: A61G 2203/32 for force
• CPC Class Codes: A61J 1/062 Carpules
• CPC Class Codes: A61K 38/2278 Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
• CPC Class Codes: A61K 38/26 Glucagons
• CPC Class Codes: A61K 38/28 Insulins
• CPC Class Codes: A61M 2005/16863 Occlusion detection
• CPC Class Codes: A61M 2205/15 Detection of leaks
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/332 Force measuring means
• CPC Class Codes: A61M 2205/3324 PH measuring means
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/3592 using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/8212 with means or measures taken for minimising energy consumption
• CPC Class Codes: A61M 2205/8293 Solar
• CPC Class Codes: A61M 5/1456 with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
• CPC Class Codes: A61M 5/14566 with a replaceable reservoir for receiving a piston rod of the pump
• CPC Class Codes: A61M 5/16854 by monitoring line pressure
• CPC Class Codes: A61M 5/172 : electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61M 5/24 : Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/31511 : Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61M 5/31515 : Connection of piston with piston rod
• CPC Class Codes: A61M 5/31525 : Dosing burettes, pipettes B01L3/02
• CPC Class Codes: H04B 10/1141 : One-way transmission
• CPC Class Codes: H04B 10/807 : Optical power feeding, i.e. transmitting power using an optical signal

Abstract

A container designed to contain a fluid medicament and adapted to cooperate with a delivery device for delivering the fluid medicament comprises an electrically operable sensor system for measuring at least one physical or chemical parameter value related to the container and/or fluid medicament therein, wherein the sensor system comprises an optical receiver designed to receive optical radiation energy and to transform said optical radiation energy into electrical energy for operating the sensor system.

Claims

1. A container designed to contain a fluid medicament and adapted to cooperate with a delivery device for delivering the fluid medicament, wherein the container comprises an electrically operable sensor system for measuring at least one physical or chemical parameter value related to the container and/or the fluid medicament therein, and wherein the sensor system comprises

(a) an optical receiver designed to receive a first optical signal and to transform said first optical signal into a first electrical signal processable by the sensor system, and

(b) an optical transmitter designed to receive a second electrical signal and to transform the second electrical signal into a second optical signal;

wherein the container is closed on one end by a movable bung, wherein the movable bung is composed of a material that is essentially transparent, and

wherein the sensor system is positioned such that the first optical signal and the second optical signal follow respective optical paths through at least a portion of the movable bung.

2. A container according to claim 1, wherein the optical receiver comprises an optical decoder designed to receive the first optical signal and to transfer the first optical signal into the first electrical signal processable by the sensor system.

3. A container according to claim 1, wherein the sensor system comprises a sensor for measuring a pressure in the fluid medicament.

4. A container according to claim 1, wherein the sensor system comprises a sensor for measuring a force applied on the fluid medicament by the cooperating delivery device.

5. A delivery device for delivering a fluid medicament from a container according to claim 1, wherein the delivery device comprises a control unit comprising an optical radiation source designed to emit optical radiation receivable by the optical receiver of the container.

6. A delivery device according to claim 5, wherein the sensor system comprises a sensor for measuring a force applied on the movable bung by the piston rod.

7. A delivery device according to claim 5, further comprising a signal processing unit designed to receive and process the second optical signal, wherein the signal processing unit comprises a photoelement.

8. A delivery device according to claim 5, wherein the control unit and the optical radiation source are integrated.

9. A delivery device according to claim 5, wherein the optical radiation source comprises a light emitting device.

10. The delivery device of claim 5, further comprising a piston rod positioned to engage the movable bung, wherein the control unit is coaxially aligned with the piston rod, and wherein the piston rod is composed of a material that is essentially transparent and forms a respective optical path for each of the first optical signal and the second optical signal.

11. A delivery device for delivering a fluid medicament from a container comprising

a piston rod,

an electrically operable sensor system for measuring at least one physical or chemical parameter value related to the container and/or the fluid medicament therein, wherein the container is a cartridge which is closed in one end by a movable bung operable by the piston rod, and wherein the sensor system is arranged between the piston rod and the movable bung, and

a control unit, wherein the control unit comprises an optical radiation source, wherein the sensor system comprises an optical receiver designed to receive optical radiation energy emitted by the optical radiation source and to transform said optical radiation energy into electrical energy for operating the sensor system, and wherein the control unit comprises a signal processing unit designed to receive and process an optical signal from the sensor system.

12. A delivery device according to claim 11, wherein the control unit is placed in a body of the delivery device and coaxially aligned to the piston rod and wherein the control unit is controllable by a control logic of the delivery device.

13. A delivery device according to claim 11, wherein the optical signal is a second optical signal, wherein the optical receiver comprises an optical decoder designed to receive a first optical signal and to transform the first optical signal into a first electrical signal processable by the sensor system and wherein the optical radiation source comprises an optical encoder designed to send the first optical signal.

14. A delivery device according to claim 13, wherein the sensor system comprises an optical transmitter designed to receive a second electrical signal, transform the second electrical signal into the second optical signal, and transmit the second optical signal.

15. The delivery device of claim 11, wherein the control unit is coaxially aligned with the piston rod, and wherein the piston rod is composed of a material that is essentially transparent and forms an optical path for the optical radiation energy along the piston rod.

16. A method for monitoring a delivery device, the delivery device comprising, a piston rod,

an electrically operable sensor system for measuring at least one physical or chemical parameter value related to the container and/or the fluid medicament therein, wherein the container is a cartridge which is closed in one end by a movable bung operable by the piston rod, and wherein the sensor system is arranged between the piston rod and the movable bung, and

a control unit, wherein the control unit comprises an optical radiation source, wherein the sensor system comprises an optical receiver designed to receive optical radiation energy emitted by the optical radiation source and to transform said optical radiation energy into electrical energy for operating the sensor system, and wherein the control unit comprises a signal processing unit designed to receive and process an optical signal from the sensor system,

the delivery device adapted for delivering fluid medicament from a container designed to contain a fluid medicament and adapted to cooperate with a delivery device for delivering the fluid medicament, wherein the container comprises an electrically operable sensor system for measuring at least one physical or chemical parameter value related to the container and/or the fluid medicament therein, and wherein the sensor system comprises

(a) an optical receiver designed to receive a first optical signal and to transform said first optical signal into a first electrical signal processable by the sensor system, and

(b) an optical transmitter designed to receive a second electrical signal and to transform the second electrical signal into a second optical signal;

wherein the container is closed on one end by a movable bung, wherein the movable bung is composed of a material that is essentially transparent, and

wherein the sensor system is positioned such that the first optical signal and the second optical signal follow respective optical paths through at least a portion of the movable bung,

wherein the sensor system comprises a sensor for measuring a pressure in the fluid medicament, and

wherein the variation of the pressure in the fluid medicament during delivery is determined and an alarm or a status signal is issued by the control unit when the determined pressure value deviates from a predefined relationship for an undamaged delivery line.

17. A container designed to contain a fluid medicament and adapted to cooperate with a delivery device for delivering the fluid medicament,

wherein the container comprises an electrically operable sensor system for measuring at least one physical or chemical parameter value related to the container and/or the fluid medicament therein, and

wherein the sensor system is arranged inside the container and comprises

(a) an optical receiver designed to receive optical radiation energy emitted by an optical radiation source and to transform said optical radiation energy into electrical energy for operating the sensor system,

(b) a sensor adapted to measure at least one physical or chemical parameter, and

(c) an optical transmitter designed to receive an electrical signal from the sensor and to transform the electrical signal into an optical signal and to optically transmit it.

18. A delivery device adapted to cooperate with a container for delivering a fluid medicament from the container,

wherein the container comprises an electrically operable sensor system for measuring at least one physical or chemical parameter value related to the container and/or the fluid medicament therein, and

wherein the sensor system is arranged inside the container and comprises

(a) an optical receiver designed to receive optical radiation energy emitted by an optical radiation source and to transform said optical radiation energy into electrical energy for operating the sensor system,

(b) a sensor adapted to measure at least one physical or chemical parameter, and

(c) an optical transmitter designed to receive an electrical signal from the sensor and to transform the electrical signal into an optical signal and to optically transmit it,

the delivery device comprising a control unit comprising an optical radiation source designed to emit optical radiation receivable by the optical receiver of the container.