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Controlling the activity of growth factors, particularly TGF-β, in vivo

  • US 10,092,891 B2
  • Filed: 04/25/2014
  • Issued: 10/09/2018
  • Est. Priority Date: 04/25/2014
  • Status: Active Grant
First Claim
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1. A method of releasing active TGF-β

  • from a latent TGF-β

    complex in which it is sequestered, comprising;

    a. conjugating the latent TGF-β

    complex to a magnetic nanoparticle; and

    b. exposing the resulting conjugate to a radiofrequency magnetic field between approximately 100 kHz and 1 MHz, wherein the magnetic field heats the magnetic nanoparticle sufficient to release active TGF-β

    from the latent TGF-β

    complex.

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