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Leukemia methylation markers and uses thereof

  • US 10,093,986 B2
  • Filed: 02/16/2017
  • Issued: 10/09/2018
  • Est. Priority Date: 07/06/2016
  • Status: Active Grant
First Claim
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1. A method of detecting a methylation pattern of a set of biomarkers in a subject suspected of having leukemia, the method comprising:

  • a) processing an extracted genomic DNA with a deaminating agent to generate a genomic DNA sample comprising deaminated nucleotides, wherein the extracted genomic DNA is obtained from a biological sample from the subject suspected of having leukemia; and

    b) detecting the methylation pattern of one or more biomarkers selected from;

    cg08261841, cg09247255, cg00142402, cg16274678, and cg02381853 from the extracted genomic DNA by contacting the extracted genomic DNA with a set of probes, wherein the set of probes hybridizes to the one or more biomarkers, and perform a DNA sequencing analysis to determine the methylation pattern of the one or more biomarkers.

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