×

Engineered renal tissues, arrays thereof, and methods of making the same

  • US 10,094,821 B2
  • Filed: 09/08/2016
  • Issued: 10/09/2018
  • Est. Priority Date: 10/06/2014
  • Status: Active Grant
First Claim
Patent Images

1. A three-dimensional, engineered, bioprinted, biological renal tubule model comprising:

  • (a) a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and

    (b) a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells; and

    (c) a layer of basement membrane between the layer of renal interstitial tissue and the layer of renal epithelial tissue, to form the three-dimensional, engineered, biological renal tubule model;

    wherein the fibroblasts and endothelial cells are present in a ratio of fibroblasts to endothelial cells at which the renal tubule model is planar six days post-printing.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×