System and method for improved determination of a brain response state

• US 10,098,562 B2
• Filed: 03/05/2013
• Issued: 10/16/2018
• Est. Priority Date: 03/05/2012
• Status: Active Grant

• Current Assignee: SensoDetect AB
• Original Assignee: SensoDetect AB
• Inventors: Kallstrand, Johan
• Primary Examiner(s): Natnithithadha, Navin
• Application Number:
  US14/381,916
• Publication Number:
  US 20150073293A1
• Time in Patent Office: 2,051 Days
• Field of Search: 600544, 600545
• CPC Class Codes: A61B 5/165 Evaluating the state of mind, e.g. depression, anxiety
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/38 Acoustic or auditory stimuli
• CPC Class Codes: A61B 5/4088 Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
• CPC Class Codes: A61B 5/4848 Monitoring or testing the effects of treatment, e.g. of medication

Abstract

A device and a method for detecting a brain response state of a subject id disclosed. The detection comprises repeatedly presenting the subject with a sound stimulus for evoking a brain response. Detecting the evoked brain response signal related to each of said sound stimulus. Determining a window having a time width covering at least partly an area of at least one neuron'"'"'s evoked response in the brain response signal. Calculating an average response signal over the window and comparing the at least one neuron'"'"'s evoked response with the average response signal for determining a cellular variance and/or volatility.

Claims

1. A method for detecting a brain response state of a subject, said method comprising:

repeatedly presenting a sound stimulus to a subject;

detecting evoked brainstem response signals during said repeatedly presenting said sound stimulus and storing said detected evoked brainstem response signals on a brainstem information storage device;

wherein each of said evoked brainstem response signals is an electrophysiological signal comprising at least one peak from at least one neuron related to each of said sound stimulus;

displaying using a computer a brainstem response display showing an average evoked response signal within a predetermined time window;

said average evoked response signal being calculated based on said evoked brainstem response signals occurring during said predetermined time window;

displaying using said computer in said brainstem response display either

     1) each of said evoked brainstem response signals occurring during said predetermined time window, or

     2) subparts of said evoked brainstem response signals occurring during said predetermined time window;

wherein said evoked brainstem response signals or said subparts of said evoked brainstem response signals are positioned in said brainstem response display to show a variance relative to said average evoked response signal.

2. The method for detecting a brain response state of claim 1, wherein said evoked brainstem response signals or said subparts of said evoked brainstem response signals are aligned with said averaged evoked response signal so as to display said variance.

3. The method for detecting a brain response state of claim 1, wherein said variance is displayed as a difference in amplitude of said evoked brainstem response signals or said subparts of said evoked brainstem response signals and said averaged evoked response signal.

4. The method for detecting a brain response state of claim 1, wherein said variance is displayed as a difference in latency of said evoked brainstem response signals or said subparts of said evoked brainstem response signals and said averaged evoked response signal.

5. The method for detecting a brain response state of claim 1, wherein said average evoked response signal is calculated by said computer based on a subseries of said evoked brainstem response signals.

6. The method for detecting a brain response state of claim 1, wherein said sound stimulus comprises a first consecutive train of modified sound pulses and a second consecutive train of modified sound pulses.

7. A device for detecting a brain response state of a subject, comprising:

a sound stimuli generating unit configured to repeatedly generate a sound stimulus to said subject;

a detection electrode configured to detect evoked brainstem response signals while said sound stimuli generating unit generates said sound stimulus;

wherein each of said evoked brainstem response signals is an electrophysiological signal comprising at least one peak from at least one neuron related to each of said sound stimulus;

a brainstem information storage device configured to receive and store said evoked brainstem response signals; and

,

a computer executing software that calculates an average evoked response signal over a predetermined length of time;

said average evoked response signal comprising either

     1) an average of said evoked brainstem response signals during said predetermined length of time;

or

     2) based on one of said evoked brainstem response signals during said predetermined length of time;

wherein said software displays on said computer said average evoked response signal during said predetermined length of time, and either

     1) each of said evoked brainstem response signals occurring during said predetermined time window, or

     2) subparts of said evoked brainstem response signals occurring during said predetermined time window;

wherein said evoked brainstem response signals or said subparts of said evoked brainstem response signals are positioned on said computer to show a variance relative to said average evoked response signal.

8. The device of claim 7, wherein said evoked brainstem response signals or said subparts of said evoked brainstem response signals are aligned with said averaged evoked response signal so as to display said variance.

9. The device of claim 7, wherein said variance is displayed as a difference in amplitude of said evoked brainstem response signals or said subparts of said evoked brainstem response signals and said averaged evoked response signal.

10. The device of claim 7, wherein said variance is displayed as a difference in latency of said evoked brainstem response signals or said subparts of said evoked brainstem response signals and said averaged evoked response signal.

11. The device of claim 7, wherein said average evoked response signal is calculated by said computer based on a subseries of said evoked brainstem response signals.

12. The device of claim 7, wherein said sound stimulus comprises a first consecutive train of modified sound pulses and a second consecutive train of modified sound pulses.

13. A method for detecting a brain response state of a subject, said method comprising:

repeatedly presenting a sound stimulus to a subject;

detecting evoked brainstem response signals during said repeatedly presenting said sound stimulus and storing said detected evoked brainstem response signals on a brainstem information storage device;

wherein each of said evoked brainstem response signals is an electrophysiological signal comprising at least one peak from at least one neuron related to each of said sound stimulus;

calculating using a computer an average evoked response signal within a predetermined time window;

said average evoked response signal being calculated based on said evoked brainstem response signals occurring during said predetermined time window;

displaying using said computer a plurality of variance levels at positions along said predetermined time window;

said plurality of variance levels calculated by said computer by determined a difference between said average evoked response signal and either

     1) each of said evoked brainstem response signals occurring during said predetermined time window, or

     2) subparts of said evoked brainstem response signals occurring during said predetermined time window.

14. The method for detecting a brain response state of claim 13, wherein said evoked brainstem response signals or said subparts of said evoked brainstem response signals are aligned with said averaged evoked response signal so as to display said variance.

15. The method for detecting a brain response state of claim 13, wherein said variance is displayed as a difference in amplitude of said evoked brainstem response signals or said subparts of said evoked brainstem response signals and said averaged evoked response signal.

16. The method for detecting a brain response state of claim 13, wherein said variance is displayed as a difference in latency of said evoked brainstem response signals or said subparts of said evoked brainstem response signals and said averaged evoked response signal.

17. The method for detecting a brain response state of claim 13, wherein said average evoked response signal is calculated by said computer based on a subseries of said evoked brainstem response signals.

18. The method for detecting a brain response state of claim 13, wherein said sound stimulus comprises a first consecutive train of modified sound pulses and a second consecutive train of modified sound pulses.