Treatment of erectile dysfunction using remote ischemic conditioning

• US 10,098,779 B2
• Filed: 03/12/2014
• Issued: 10/16/2018
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: Hospital For SICK Children
• Original Assignee: Hospital For SICK Children
• Inventors: Caldarone, Christopher
• Primary Examiner(s): Lacyk, John
• Application Number:
  US14/773,919
• Publication Number:
  US 20160015553A1
• Time in Patent Office: 1,679 Days
• Field of Search: 600 38- 41
• CPC Class Codes: A61F 2005/414 by constricting means
• CPC Class Codes: A61F 2005/415 by inflatable means
• CPC Class Codes: A61F 5/41 Devices for promoting penis erection penis implants A61F2/26; massage of the genitals A61H19/00
• CPC Class Codes: A61H 1/008 Apparatus for applying pressure or blows almost perpendicular to the body or limb axis, e.g. chiropractic devices for repositioning vertebrae, correcting deformation
• CPC Class Codes: A61H 9/0078 with intermittent or alternately inflated bladders or cuffs mattresses for preventing bed-sores with alternated pressurized chambers A61G7/05776

Abstract

The invention contemplates use of remote ischemic conditioning in the treatment of erectile dysfunction.

Claims

1. A method for treating erectile dysfunction comprising

performing remote ischemic conditioning (RIC) on a subject that has experienced or is experiencing erectile dysfunction, to treat erectile dysfunction,

wherein RIC comprises two cycles, each cycle comprises a one minute of blood flow occlusion period followed by a reperfusion period, and wherein a second or subsequent cycle begins upon conclusion of the reperfusion period of a previous cycle.

2. The method of claim 1, wherein the RIC is chronic RIC.

3. The method of claim 1, wherein the RIC is acute RIC.

4. The method of claim 2, wherein RIC is performed on a daily basis.

5. The method of claim 2, wherein RIC is performed more than once a day.

6. The method of claim 3, wherein RIC is performed within 24 hours, within 12 hours, within 6 hours, within 4 hours, within 2 hours, within 1 hour, or within 30 minutes prior to intercourse or other activity requiring an erect penis.

7. The method of claim 1, wherein RIC comprises 3, 4, or 5 cycles.

8. The method of claim 1, wherein each cycle comprises a 5 minute blood occlusion period and a 5 minute reperfusion period.

9. The method of claim 1, wherein RIC is performed repeatedly at the same site.

10. The method of claim 9, wherein RIC is performed repeatedly on an upper limb.

11. The method of claim 9, wherein RIC is performed repeatedly on a lower limb.

12. The method of claim 1, wherein the subject is receiving a second therapy to treat erectile dysfunction.

13. The method of claim 12, wherein the second therapy is administered at less than a maximum tolerable dose.

14. The method of claim 12, wherein the second therapy is administered at greater than a maximum tolerable dose.