Coating for intraluminal expandable catheter providing contact transfer of drug micro-reservoirs
First Claim
Patent Images
1. A catheter comprising:
- an expandable portion on an elongated body; and
a first coating over an outer surface of the expandable portion, wherein the first coating comprises;
a hydrophobic matrix, wherein the hydrophobic matrix comprises a cholesterol and a fatty acid; and
a dispersed phase comprising a plurality of micro-reservoirs dispersed in the hydrophobic matrix, wherein the plurality of micro-reservoirs comprises a first active agent and a biodegradable or bioerodable polymer; and
wherein at least a portion of the first coating will transfer to a luminal surface when the expandable portion is expanded at a treatment site, and transfers at least a portion of the plurality of micro-reservoirs to the luminal surface.
1 Assignment
0 Petitions
Accused Products
Abstract
A coating for an expandable portion of a catheter comprising a hydrophobic matrix and a dispersed phase is disclosed. The dispersed phase comprises a plurality of micro-reservoirs dispersed in the hydrophobic matrix, wherein the plurality of micro-reservoirs comprises a first active agent and a first biodegradable or bioerodable polymer. A coating formulation and a method for forming the coating are also disclosed. A catheter comprising the coating on the expandable portion and a method for treating a condition are also provided.
-
Citations
44 Claims
-
1. A catheter comprising:
-
an expandable portion on an elongated body; and a first coating over an outer surface of the expandable portion, wherein the first coating comprises; a hydrophobic matrix, wherein the hydrophobic matrix comprises a cholesterol and a fatty acid; and a dispersed phase comprising a plurality of micro-reservoirs dispersed in the hydrophobic matrix, wherein the plurality of micro-reservoirs comprises a first active agent and a biodegradable or bioerodable polymer; and wherein at least a portion of the first coating will transfer to a luminal surface when the expandable portion is expanded at a treatment site, and transfers at least a portion of the plurality of micro-reservoirs to the luminal surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 42, 43, 44)
-
-
27. A method for coating an expandable portion of a catheter such that at least a portion of the coating transfers to a luminal surface at a treatment site upon expansion of the expandable portion, the method comprises:
-
disposing a coating formulation onto the surface of an expanded expandable portion of the catheter wherein the coating formulation comprises; a plurality of micro-reservoirs, wherein the plurality of micro-reservoirs comprise a first active agent intermixed with or dispersed in a biodegradable or bioerodable polymer; at least one hydrophobic compound wherein the hydrophobic compound comprises a cholesterol and a fatty acid or a cholesterol and a phospholipid, wherein the phospholipid comprises an acyl chain phospholipid with an acyl chain length of about 20 to about 34; and a fluid, wherein the fluid is selected from the group consisting of pentane, hexane, heptane, heptane, and fluorocarbon mixture, alcohol and fluorocarbon mixture, and alcohol and water mixture; and evaporating the fluid; and collapsing the expandable portion; and wherein the plurality of micro-reservoirs are dispersed in a hydrophobic matrix formed by the at least one hydrophobic compound. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
-
Specification