Drive mechanism for a drug delivery device

• US 10,099,015 B2
• Filed: 04/08/2014
• Issued: 10/16/2018
• Est. Priority Date: 04/10/2013
• Status: Expired due to Fees

• Current Assignee: Sanofi
• Original Assignee: Sanofi
• Inventors: Bayer, Stefan, Berning, Daniel, Blank, Philippe, Pelzer, Wolfgang, Pfoser, Michael, Wilden, Bjorn
• Primary Examiner(s): Gilbert, Andrew
• Assistant Examiner(s): Ulsh, Dung
• Application Number:
  US14/783,160
• Publication Number:
  US 20160045668A1
• Time in Patent Office: 1,652 Days
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/582 by tactile feedback
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/315 Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
• CPC Class Codes: A61M 5/31501 Means for blocking or restricting the movement of the rod or piston A61M5/5013 takes precedence
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61M 5/31525 Dosing burettes, pipettes B01L3/02
• CPC Class Codes: A61M 5/3153 by single stroke limiting means
• CPC Class Codes: A61M 5/31533 Dosing mechanisms, i.e. setting a dose administrating mechanisms A61M5/31565
• CPC Class Codes: A61M 5/31541 Means preventing setting of a dose beyond the amount remaining in the cartridge
• CPC Class Codes: A61M 5/31543 piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
• CPC Class Codes: A61M 5/31545 Setting modes for dosing
• CPC Class Codes: A61M 5/31553 without axial movement of dose setting member
• CPC Class Codes: A61M 5/31563 interacting with a displaceable stop member
• CPC Class Codes: A61M 5/31565 Administration mechanisms, i.e. constructional features, modes of administering a dose dosing mechanisms for setting a dose A61M5/31533
• CPC Class Codes: A61M 5/31583 based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
• CPC Class Codes: A61M 5/31585 performed by axially moving actuator, e.g. an injection button

Abstract

The present invention relates to a drive mechanism for a drug delivery device for dispensing of a dose of a medicament, and to a respective drug delivery device, wherein the drive mechanism comprises: —an elongated housing (30) extending in an axial direction (1, 2), —a piston rod (80) to operably engage with a piston (16) of a cartridge (14) to displace the piston (16) in axial distal direction (1), —a drive sleeve (60) extending in axial direction (1, 2) and being rotatably supported in the housing (30), —a dose setting member (40) rotatably supported on a side wall portion (31) of the housing (30) and being rotatable with respect to an axis (41) extending in radial direction (r), —wherein the drive sleeve (60) is operably releasable from the piston rod (80) and rotatably engageable with the dose setting member (40) for setting of the dose.

Claims

1. A drive mechanism of a drug delivery device for dispensing of a dose of a medicament, the drive mechanism comprising:

an elongated housing extending in an axial direction;

a piston rod to operably engage with a piston of a cartridge to displace the piston in an axial distal direction;

a drive sleeve extending in the axial direction and being rotatably supported in the elongated housing; and

a dose setting member rotatably supported on a side wall portion of the elongated housing and being rotatable with respect to an axis extending in a radial direction relative to the axial direction, the dose setting member comprising a radially inwardly extending shaft relative to the elongated housing,

wherein the drive sleeve is operably releasable from the piston rod and rotatably engageable with the dose setting member via the radially inwardly extending shaft for setting of the dose, and

wherein the drive sleeve is displaceable in the axial direction between a proximal dose setting position and a distal dose injecting position for selectively and alternately engaging and disengaging with the piston rod and with the dose setting member.

2. The drive mechanism according to claim 1, wherein the drive sleeve is operably engageable with the piston rod and operably releasable from the dose setting member for dispensing of the dose.

3. The drive mechanism according to claim 1, further comprising a dose injection member at a proximal end of the elongated housing, wherein the dose injection member is displaceable in the axial direction between a proximal dose setting position and a distal dose injecting position and distally abuts with the drive sleeve for displacing the drive sleeve into the distal dose injecting position.

4. The drive mechanism according to claim 3, wherein the dose injection member is rotatably fixed to the elongated housing and comprises a locking member to engage with the dose setting member when reaching the distal dose injecting position.

5. The drive mechanism according to claim 3, wherein the drive sleeve is displaceable in the axial distal direction relative to the elongated housing against an action of a spring element axially acting between the drive sleeve and the elongated housing.

6. The drive mechanism according to claim 1, wherein the dose setting member comprises a gearwheel to engage with a crown wheel of the drive sleeve when in a dose setting position.

7. The drive mechanism according to claim 1 wherein the radially inwardly extending shaft is a hollow shaft and further comprising a support member fixedly attached to the elongated housing and having a radially outwardly extending socket portion to support the hollow shaft of the dose setting member.

8. The drive mechanism according to claim 7, wherein the support member further comprises an axially extending receptacle at a proximal end to slidably receive the dose injection member.

9. The drive mechanism according to claim 7, wherein a last dose limiting member is arranged between the socket portion and the hollow shaft, wherein the last dose limiting member is threadedly engaged with the socket portion and is rotatably fixed and slidably displaceable relative to the hollow shaft.

10. The drive mechanism according to claim 9, wherein the last dose limiting member is displaceable along the socket portion between a zero dose limiting stop and a last dose limiting stop radially extending from opposite end portions of the socket portion or the hollow shaft.

11. The drive mechanism according to claim 1, wherein the drive sleeve is rotatably and axially slidably engaged with a dose indicating sleeve threadedly engaged with an inside of the elongated housing, wherein the dose indicating sleeve comprises at least one stop at one axial end to abut with a single dose limiting stop located on the inside of the elongated housing.

12. The drive mechanism according to claim 1, wherein the drive sleeve is rotatably biased relative to the elongated housing by a helical spring extending around the drive sleeve.

13. The drive mechanism according to claim 1, wherein the piston rod is threadedly engaged with a drive nut axially fixed to the elongated housing and being rotatably supported in the elongated housing, wherein the drive sleeve is rotatably engaged with the drive nut when in a dose injecting position and wherein the drive sleeve and the drive nut are disengaged when the drive sleeve is in a dose setting position.

16. The drive mechanism according to claim 1, wherein the radially inwardly extending shaft extends radially inwardly into the elongated housing.

17. The drive mechanism according to claim 1, wherein the radially inwardly extending shaft comprises an outwardly extending toothed surface engageable with a crown wheel of the drive sleeve.

18. The drive mechanism according to claim 1, wherein the dose setting member comprises an actuation wheel located outside the side wall portion of the elongated housing.

19. The drive mechanism according to claim 18, wherein a diameter of the actuation wheel is larger than a diameter of the radially inwardly extending shaft.

14. A drug delivery device for dispensing of a dose of a medicament, the drug delivery device comprising:

a drive mechanism comprising;

an elongated housing extending in an axial direction;

a piston rod to operably engage with a piston of a cartridge to displace the piston in an axial distal direction;

a drive sleeve extending in the axial direction and being rotatably supported in the elongated housing; and

a dose setting member rotatably supported on a side wall portion of the elongated housing and being rotatable with respect to an axis extending in a radial direction relative to the axial direction, the dose setting member comprising a radially inwardly extending shaft relative to the elongated housing,

wherein the drive sleeve is operably releasable from the piston rod and rotatably engageable with the dose setting member via the radially inwardly extending shaft for setting of the dose, and

wherein the drive sleeve is displaceable in the axial direction between a proximal dose setting position and a distal dose injecting position for selectively and alternately engaging and disengaging with the piston rod and with the dose setting member; and

the cartridge at least partially filled with the medicament and being arranged in the elongated housing of the drive mechanism or in a cartridge holder fixed to the elongated housing.

15. The drug delivery device according to claim 14, wherein the drive sleeve is operably engageable with the piston rod and operably releasable from the dose setting member for dispensing of the dose.