Devices, systems and methods for medicament delivery

• US 10,099,023 B2
• Filed: 03/04/2016
• Issued: 10/16/2018
• Est. Priority Date: 02/01/2005
• Status: Expired due to Fees

• Current Assignee: Kaleo, Inc.
• Original Assignee: Kaleo, Inc.
• Inventors: Edwards, Eric S., Edwards, Evan T., Licata, Mark J., Meyers, Paul F., Weinzierl, David A.
• Primary Examiner(s): Schmidt, Emily
• Application Number:
  US15/061,462
• Publication Number:
  US 20160184535A1
• Time in Patent Office: 956 Days
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/582 by tactile feedback
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 2205/587 Lighting arrangements
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 35/00 Devices for applying media, e.g. remedies, on the human body devices for handling toiletry or cosmetic substances A45D; absorbent pads, e.g. swabs, A61F13/15
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/2046 Media being expelled from injector by gas generation, e.g. explosive charge
• CPC Class Codes: A61M 5/2053 Media being expelled from injector by pressurised fluid or vacuum for infusion A61M5/145, A61M5/155
• CPC Class Codes: A61M 5/3129 Syringe barrels A61M5/3205 and A61M5/50 take precedence
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: A61M 5/3204 Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
• CPC Class Codes: A61M 5/3234 Fully automatic needle retraction, i.e. in which triggering of the needle does not require a deliberate action by the user
• CPC Class Codes: A61M 5/326 : Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
• CPC Class Codes: A61M 5/3287 : Accessories for bringing the needle into the body; Automatic needle insertion A61M5/20, A61M5/31525 take precedence
• CPC Class Codes: A61M 5/5086 : for indicating if defective, used, tampered with or unsterile
• CPC Class Codes: G16H 20/13 : delivered from dispensers
• CPC Class Codes: G16H 20/17 : delivered via infusion or injection
• CPC Class Codes: G16Z 99/00 : Subject matter not provided for in other main groups of this subclass

Abstract

An apparatus includes a label configured to be coupled to a medicament delivery device. The label includes a first surface and a second surface. The first surface is configured to be coupled to an outer surface of the medicament delivery device. The second surface includes a textual indicia. The label further includes an electronic circuit system configured to output an electronic signal.

Claims

1. An apparatus, comprising:

a housing having a mouthpiece;

a medicament container, a proximal end portion of the medicament container disposed outside of the housing, a distal end portion of the medicament container disposed within the housing such that movement of the distal end portion of the medicament container within the housing actuates the medicament container to deliver a medicament via the mouthpiece;

an electronic circuit system configured to produce an electronic output associated with the movement of the distal end portion of the medicament container within the housing, the electronic circuit system including a printed circuit board, a processor, and a conductive trace on a substrate, the conductive trace covered by an insulative layer, the conductive trace operably coupled to the processor; and

an electronics actuator coupled to the medicament container, the electronics actuator including a protrusion within an opening defined by the printed circuit board when the electronics actuator is in a first position before movement of the medicament container, the electronics actuator configured to move within the opening defined by the printed circuit board from the first position toward a second position to deform the conductive trace in response to movement of the distal end portion of the medicament container within the housing to actuate the electronic circuit system.

2. The apparatus of claim 1, wherein the electronic circuit system includes a light output device, the electronic output including a light output produced by the light output device.

3. The apparatus of claim 1, wherein the electronic circuit system includes a light output device and a speaker, the electronic output including a light output produced by the light output device and a recorded speech output produced by the speaker.

4. The apparatus of claim 1, wherein the electronics actuator is configured to reversibly actuate the electronic circuit system.

5. The apparatus of claim 1, wherein the electronics actuator is configured to separate the conductive trace to actuate the electronic circuit system.

6. The apparatus of claim 1, wherein the electronic circuit system includes a switch including the conductive trace, the switch configured to be moved from a first state to a second state when the protrusion deforms the conductive trace.

7. The apparatus of claim 6, wherein the switch is configured to be reversibly moved between the first state and the second state.

8. The apparatus of claim 6, wherein the switch has more than two states, the switch configured to be reversibly moved between the first state and the second state.

9. The apparatus of claim 1, further comprising:

a cap configured to cover the mouthpiece, the cap including a cap protrusion configured to actuate the electronic circuit system at a first time when the cap is removed from about the mouthpiece, the protrusion of the electronics actuator configured to actuate the electronic circuit system at a second time.

10. The apparatus of claim 1, wherein:

the electronic output is a first electronic output; and

the electronic circuit system includes a motion sensor configured to detect motion of the medicament container, the electronic circuit system configured to produce a second electronic output when the motion sensor detects motion of the medicament container.

11. The apparatus of claim 1, wherein the electronic circuit system includes a battery positioned such that an electrical contact portion of the printed circuit board is in contact with a terminal of the battery.

12. An apparatus, comprising:

a housing having a mouthpiece;

a medicament container, a proximal end portion of the medicament container disposed outside of the housing, a distal end portion of the medicament container disposed within the housing such that movement of the distal end portion of the medicament container within the housing actuates the medicament container to deliver a medicament via the mouthpiece;

an electronic circuit system including a printed circuit board, a processor coupled to the printed circuit board, and a switch operably coupled to the processor, the electronic circuit system configured to produce an electronic output when the switch is moved from a first state to a second state; and

an electronics actuator coupled to and configured to move with the medicament container, the electronics actuator including a protrusion configured to move within an opening defined by and extending through the entire printed circuit board to engage the switch to change the switch from the first state to the second state in response to movement of the distal end portion of the medicament container within the housing.

13. The apparatus of claim 12, wherein the switch is configured to be reversibly moved between the first state and the second state.

14. The apparatus of claim 12, wherein the switch has more than two states, the switch configured to be reversibly moved between the first state and the second state.

15. The apparatus of claim 12, wherein:

the switch includes a conductive trace on a substrate, the conductive trace covered by an insulative layer; and

the protrusion of the electronics actuator is configured to exert a force on the conductive trace to move the switch from the first state to the second state.

16. The apparatus of claim 15, wherein the electronics actuator is configured to separate the conductive trace to actuate the electronic circuit system.

17. The apparatus of claim 12, wherein:

the switch is coupled to an actuation portion of the printed circuit board and includes a conductive trace covered by an insulative layer; and

the protrusion of the electronics actuator is configured to contact the actuation portion of the printed circuit board to move the switch from the first state to the second state.

18. The apparatus of claim 12, wherein the switch is a first switch, the electronic output is a first electronic output, the apparatus further comprising:

a cap configured to cover the mouthpiece, the cap including a protrusion, the protrusion of the cap configured to actuate a second switch when the cap is removed from about the mouthpiece, the electronic circuit system configured to produce a second electronic output when the second switch is actuated.

19. An apparatus, comprising:

a housing having a mouthpiece;

a medicament container, a proximal end portion of the medicament container disposed outside of the housing, a distal end portion of the medicament container disposed within the housing such that movement of the distal end portion of the medicament container within the housing actuates the medicament container to deliver a medicament via the mouthpiece;

an electronic circuit system including a processor, a first switch operably coupled to the processor, and a second switch operably coupled to the processor, the electronic circuit system configured to produce a first electronic output when the first switch is actuated and a second electronic output when the second switch is actuated, at least one of the first switch or the second switch includes a conductive trace on a substrate, the conductive trace covered by an insulative layer;

a cap configured to cover the mouthpiece, the cap including a first electronics actuator configured to actuate the first switch when the cap is removed from about the mouthpiece; and

a second electronics actuator coupled to the medicament container, the second electronics actuator configured to move within an opening defined by the substrate, the movement being in a direction parallel to a plane defined by the substrate to actuate the second switch when the distal end portion of the medicament container is moved within the housing, at least one of the first electronics actuator or the second electronics actuator configured to exert a force on the conductive trace to actuate the first switch or the second switch.

20. The apparatus of claim 19, wherein at least one of the first switch or the second switch is configured to be reversibly actuated.

21. The apparatus of claim 19, wherein:

the first switch includes the conductive trace and is configured to be reversibly actuated.

22. The apparatus of claim 19, wherein:

the second switch includes the conductive trace and is configured to be reversibly actuated.

23. The apparatus of claim 19, wherein:

the electronic circuit system includes a printed circuit board coupled to the processor, the first switch is coupled to an actuation portion of the printed circuit board and includes the conductive trace; and

the first electronics actuator is configured to contact the actuation portion of the printed circuit board to actuate the first switch.

24. The apparatus of claim 19, wherein the electronic circuit system includes a light output device, at least one of the first electronic output or the second electronic output including a light output produced by the light output device.

25. The apparatus of claim 19, wherein the electronic circuit system includes a light output device and a speaker, at least one of the first electronic output or the second electronic output including a light output produced by the light output device, at least one of the first electronic output or the second electronic output including a recorded speech output produced by the speaker.

26. The apparatus of claim 19, wherein the electronic circuit system includes a motion sensor configured to detect motion of the medicament container, the electronic circuit system configured to produce a third electronic output when the motion sensor detects motion of the medicament container.