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Method for inducing differentiation of pluripotent stem cells into endodermal cells

  • US 10,100,284 B2
  • Filed: 12/24/2014
  • Issued: 10/16/2018
  • Est. Priority Date: 12/25/2013
  • Status: Active Grant
First Claim
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1. A composition for inducing differentiation of pluripotent stem cells into hepatocytes and/or liver precursor cells, comprising:

  • a pharmaceutically acceptable carrier; and

    a synthetic peptide comprising;

    a stem cell differentiation-inducing peptide sequence that induces differentiation of pluripotent stem cells into hepatocytes and/or liver precursor cells, anda transmembrane peptide sequence at the N end of or C end of the amino acid sequence of the stem cell differentiation-inducing peptide sequence,wherein the total number of amino acid residues constituting the synthetic peptide is 100 or less amino acid residues,the transmembrane peptide sequence is selected from the amino acid sequences represented by any of SEQ ID NOs;

    7 to 15, andthe stem cell differentiation-inducing peptide sequence is selected from the amino acid sequences of i) through iv) below;

    i) Amino acid sequence of SEQ ID NO;

    1 below;

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