Remotely powered, multisite sensing system with a shared, two-wire bus for power and communication

• US 10,102,178 B2
• Filed: 04/07/2017
• Issued: 10/16/2018
• Est. Priority Date: 01/13/2014
• Status: Active Grant

• Current Assignee: Senseonics, Incorporated (Senseonics Holdings, Inc.)
• Original Assignee: Senseonics, Incorporated (Senseonics Holdings, Inc.)
• Inventors: DeHennis, Andrew
• Primary Examiner(s): White, Dennis Michael
• Application Number:
  US15/482,141
• Publication Number:
  US 20170212863A1
• Time in Patent Office: 557 Days
• CPC Class Codes: G01N 33/50 Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing measuring or testing processes involving enzymes or microorganisms, compositions or test papers therefor; processes for forming such compositions, condition responsive control in microbiological or enzymological processes C12Q
• CPC Class Codes: G06F 1/3209 Monitoring remote activity, e.g. over telephone lines or network connections
• CPC Class Codes: G06F 13/287 Multiplexed DMA G06F13/30 takes precedence
• CPC Class Codes: G06F 13/404 with address mapping
• CPC Class Codes: G06F 13/4282 on a serial bus, e.g. I2C bus, SPI bus on daisy chain buses G06F13/4247
• CPC Class Codes: H02J 50/10 using inductive coupling
• CPC Class Codes: H04B 5/24 Inductive coupling
• CPC Class Codes: H04B 5/79 for data transfer in combination with power transfer
• CPC Class Codes: Y02D 10/00 Energy efficient computing, e.g. low power processors, power management or thermal management

Abstract

A multisite sensing system including two or more analyte sensors, an interface device, and a shared bus. The interface device may be configured to receive a power signal and generate power for powering the analyte sensors and to convey data signals generated by the analyte sensors. The shared bus connected to the interface device and each of the analyte sensors and configured to provide the power generated by the interface device to the analyte sensors and to provide the data signals generated by the analyte sensors to the interface device. The interface device may be an inductive element. The shared bus may be a two wire, multiplexed bus. The analyte sensors may be spatially separated for analyte sensing at least two different locations. The analyte sensors may generate data signals indicative of the presence and/or amount of the same analyte or of one or more different analytes.

Claims

1. A multisite sensing system comprising:

a first analyte sensor comprising;

a first analyte indicator configured to exhibit a detectable property based on an amount or concentration of a first analyte in proximity to the first analyte indicator; and

one or more first circuit components configured to generate a first data signal based on the detectable property exhibited by the first analyte indicator, wherein the one or more first circuit components include a first analog-to-digital converter;

a second analyte sensor comprising;

a second analyte indicator configured to exhibit a detectable property based on an amount or concentration of a second analyte in proximity to the second analyte indicator; and

one or more second circuit components configured to generate a second data signal based on the detectable property exhibited by the second analyte indicator, wherein the one or more second circuit components include a second analog-to-digital converter;

wherein the first analyte indicator and the one or more first circuit components are not part of the second analyte sensor, and the second analyte indicator and the one or more second circuit components are not part of the first analyte sensor;

an interface device configured to convey the first and second data signals to a transceiver external to the multisite sensing system; and

a shared bus (a) connected to the interface device, the first analyte sensor, and the second analyte sensor and (b) configured to provide the first and second data signals from the first and second analyte sensors to the interface device;

wherein the first analyte indicator is spatially separated from the second analyte indicator for analyte sensing at least at two different analyte indicator locations.

2. The multisite sensing system of claim 1, wherein the shared bus is a multiplexed bus.

3. The multisite sensing system of claim 1, further comprising a third analyte sensor comprising:

a third analyte indicator configured to exhibit a detectable property based on an amount or concentration of a third analyte in proximity to the third analyte indicator; and

one or more third circuit components configured to generate a third data signal based on the detectable property exhibited by the third analyte indicator;

wherein the first analyte indicator, the second analyte indicator, the one or more first circuit components, and the one or more second circuit components are not part of the third analyte sensor, and the third analyte indicator and the one or more third circuit components are neither part of the first analyte sensor nor part of the second analyte sensor.

4. The multisite sensing system of claim 1, wherein the interface device is an antenna.

5. The multisite sensing system of claim 1, wherein the interface device is an inductive element.

6. The multisite sensing system of claim 1, wherein the interface device is a coil.

7. The multisite sensing system of claim 1, wherein the first analyte and the second analyte are the same analyte.

8. The multisite sensing system of claim 1, wherein the second analyte is different than the first analyte.

9. The multisite sensing system of claim 1, wherein the first analyte indicator is a polymer graft including indicator molecules.

10. The multisite sensing system of claim 1, wherein the one or more first circuit components include a light source and a light detector.

11. The multisite sensing system of claim 1, wherein first analyte sensor comprises a substrate, and one or more circuit components of the one or more first circuit components is fabricated in or mounted on the substrate.

12. The multisite sensing system of claim 1, further comprising a housing containing the first and second analyte sensors, shared bus, and interface device.

13. The multisite sensing system of claim 12, wherein first indicator element is embedded within and/or covers at least a first portion of the housing, and the second indicator element is embedded within and/or covers at least a second portion of the housing.

14. The multisite sensing system of claim 1, wherein the shared bus consists of two wires each connected to the interface device, the first analyte sensor, and the second analyte sensor.

15. The multisite sensing system of claim 1, wherein one or more of the first analyte sensor and the second analyte sensor is an optical sensor.

16. The multisite sensing system of claim 1, wherein one or more of the first analyte sensor and the second analyte sensor is a chemical sensor.

17. A multisite sensing system comprising:

two or more analyte sensors;

an interface device configured to convey data signals generated by the two or more analyte sensors; and

a shared bus connected to the interface device and each of the two or more analyte sensors and configured to provide the data signals generated by the two or more analyte sensors to the interface device, wherein the shared bus consists of two wires.

18. A multisite sensing system comprising:

a first analyte sensor;

a second analyte sensor;

an interface device configured to (i) receive a command from a transceiver external to the multisite sensing system and (ii) convey data signals generated by the first and second analyte sensors to the transceiver, wherein the command includes an address; and

a shared bus connected to the interface device, the first analyte sensor, and the second analyte sensor and configured to (i) provide the command received by the interface device to the first and second analyte sensors and (ii) provide the data signals generated by the first and second analyte sensors to the interface device;

wherein the first analyte sensor comprises;

a first analyte indicator configured to exhibit a detectable property based on an amount or concentration of a first analyte in proximity to the first analyte indicator; and

one or more first circuit components configured to (i) extract the address from the command and (ii) provide a response based on the detectable property exhibited by the first analyte indicator only if the extracted address matches a first address;

wherein the second analyte sensor comprises;

a second analyte indicator configured to exhibit a detectable property based on an amount or concentration of a second analyte in proximity to the second analyte indicator; and

one or more second circuit components configured to (i) extract the address from the command and (ii) provide a response based on the detectable property exhibited by the second analyte indicator only if the extracted address matches a second address;

wherein the first address is different than the second address, and the data signals include one or more of the responses provided by the first and second analyte sensors.

19. The multisite sensing system of claim 18, wherein the interface device is configured to receive power from the transceiver and generate a current, the shared bus is configured to provide the current generated by the interface device to the first and second analyte sensors, the one or more first circuit components of the first analyte sensor and the one or more second circuit components of the second analyte sensor extract the address from modulations in the current generated by the interface device, and the first and second analyte sensors are powered by the current generated by the interface device.

20. The multisite sensing system of claim 18, wherein the first analyte and the second analyte are the same analyte.

21. The multisite sensing system of claim 18, wherein the first analyte and the second analyte are different analytes.

22. The multisite sensing system of claim 18, wherein one or more of the first analyte sensor and the second analyte sensor is an optical sensor.

23. The multisite sensing system of claim 18, wherein one or more of the first analyte sensor and the second analyte sensor is a chemical sensor.

24. The multisite sensing system of claim 18, wherein the shared bus consists of two wires each connected to the interface device, the first analyte sensor, and the second analyte sensor.