Implantable sensor

• US 10,105,081 B2
• Filed: 11/22/2016
• Issued: 10/23/2018
• Est. Priority Date: 09/09/2009
• Status: Active Grant

• Current Assignee: Indigo Diabetes NV
• Original Assignee: Indigo Diabetes NV
• Inventors: Delbeke, Danae, Baets, Roeland, Bogaerts, Wim, Ryckeboer, Eva Maria Paula
• Primary Examiner(s): Winakur, Eric
• Assistant Examiner(s): Liu, Chu Chuan (JJ)
• Application Number:
  US15/358,917
• Publication Number:
  US 20170071510A1
• Time in Patent Office: 700 Days
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: G01B 9/02044 Imaging in the frequency domain, e.g. by using a spectrometer
• CPC Class Codes: G01B 9/02051 Integrated design, e.g. on-chip or monolithic
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence
• CPC Class Codes: G02B 2006/12061 Silicon
• CPC Class Codes: G02B 2006/12107 Grating
• CPC Class Codes: G02B 2006/12123 Diode
• CPC Class Codes: G02B 2006/12138 Sensor
• CPC Class Codes: G02B 6/12021 Comprising cascaded AWG devices; AWG multipass configuration; Plural AWG devices integrated on a single chip
• CPC Class Codes: G02B 6/34 utilising prism or grating G02B6/293 takes precedence

Abstract

A sensor for sensing a substance such as for example glucose. The sensor is implantable in the body of a living creature. The sensor has a photonic integrated circuit, e.g. silicon-photonics integrated circuit, for spectrally processing radiation interacting with the sample. A continuous monitoring system can also include such a sensor.

Claims

1. A sensor configured to sense glucose, urea, creatinine, triglyceride, protein, cholesterol, ethanol, ketones, hormones or lactate, the sensor being implantable in the body of a living creature or an object and configured for sensing in tissue or bodily fluids, the sensor comprising:

an integrated radiation source configured for coupling radiation generated by said source into a photonics integrated circuit, the integrated radiation source being for irradiating said tissue or bodily fluids having at least one of glucose, urea, creatinine, triglyceride, protein, cholesterol, ethanol, ketones, hormones or lactate in said tissue or bodily fluid,

a photonics integrated circuit configured to spectrally process the radiation interacting with the glucose, urea, creatinine, triglyceride, protein, cholesterol, ethanol, ketones, hormones or lactate, wherein the photonics integrated circuit comprises at least an integrated optical waveguide, an optical demultiplexer and a detection element,

said integrated optical waveguide being configured for receiving radiation from said integrated radiation source and to send the radiation to the demultiplexer,

said optical demultiplexer being configured for spectrally processing the radiation, said integrated detection element being configured to detect different absorption or reflection bands of the glucose, urea, creatinine, triglyceride, protein, cholesterol, ethanol, ketones, hormones or lactate from the spectrally processed radiation to sense the glucose, urea, creatinine, triglyceride, protein, cholesterol, ethanol, ketones, hormones or lactate, wherein the radiation source and the photonics integrated circuit form an integrated spectrometer, and wherein said sensor is configured to be implantable in the body of a living creature or an object to sense glucose, urea, creatinine, triglyceride, protein, cholesterol, ethanol, ketones, hormones or lactate.

2. The sensor according to claim 1, wherein the sensor is waveguide based and configured for free space sensing.

3. The sensor according to claim 1, the sensor comprising a measurement region from which the radiation is captured, wherein the photonics integrated circuit and measurement region are spatially configured to allow for substance-sampling free measurements.

4. The sensor according to claim 1, wherein the photonics integrated circuit and measurement region are sized so as to allow for time-dependent substance measurements based on spontaneous displacement of the substance in the body.

5. The sensor according to claim 1, wherein the measurement region is an open-space measurement region so that it is not enclosed by sensor walls.

6. The sensor according to claim 1, wherein the integrated detecting element is a detecting element monolithically integrated with the photonics integrated circuit or heterogeneously integrated with the photonics integrated circuit or hybridly integrated with the photonics integrated circuit.

7. The sensor according to claim 1, wherein the radiation source is a radiation source monolithically integrated with the photonics integrated circuit or heterogeneously integrated with the photonics integrated circuit or hybridly integrated with the photonics integrated circuit.

8. The sensor according to claim 1, wherein the photonics integrated circuit is a silicon photonics integrated circuit.

9. The sensor according to claim 1, wherein the photonics integrated circuit based sensor is adapted for operating in at least a wavelength region of 1560 nm to 1850 nm and/or is adapted for operating in at least a wavelength region of 2080 nm to 2325 nm.

10. The sensor according to claim 1, wherein the sensor is adapted for performing said spectrally processing radiation prior to interaction of the radiation with the substance to be sensed or wherein the sensor is adapted for performing said spectrally processing radiation after interaction of the radiation with the substance.

11. The sensor according to claim 1, wherein the sensor has a sensor configuration such that a measurement region of the sensor is surrounded by components of the sensor.

12. The sensor according to claim 1, wherein a measurement region of the sensor lies substantially at one side of all components of the sensor.

13. The sensor according to claim 1, the sensor being configured for obtaining depth-related information regarding the sample.

14. The sensor according to claim 1, wherein the sensor is configured for optical coherence tomography.

15. The sensor according to claim 1, wherein the sensor is configured for spectrally resolved optical coherence tomography wherein the photonics integrated circuit comprises an interferometer and is adapted for processing obtained interference data in several different windows and/or wherein the sensor is configured for spatially resolved detection and for deriving said depth-resolved information regarding the sample based thereon.

16. The sensor according to claim 1, wherein the photonics integrated circuit is adapted for spatially resolved detection of scattered or reflected radiation and/or wherein the photonics integrated circuit comprises a plurality of cascading wavelength multiplexers for increasing a number of channels for spectrally processing radiation and/or wherein the photonics integrated circuit comprises a plurality of tunable filters for increasing a number of channels for spectrally processing radiation.

17. The sensor according to claim 1, wherein frequency or time-domain multiplexing is used for increasing a number of channels for spectrally processing radiation and/or wherein a Vernier-shifted spectral response is used for increasing a number of channels for spectrally processing radiation.

18. The sensor according to claim 1, the sensor comprising an electronics component stacked with the sensing element and radiation source, wherein the connection between sensing element and radiation source on the one hand and the electronics on the other hand is made by through silicon vias.

19. The sensor according to claim 1, the sensor being a glucose sensor or the sensor being a urea sensor or the sensor being an optical coherence tomography imager or the sensor being implantable in a bioreactor.

20. A continuous monitoring system comprising an implantable sensor according to claim 1, and a readout system for wirelessly receiving data sensed by the sensor.