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Method for representations of network-dependent features of the hemoglobin signal in living tissues for detection of breast cancer and other applications

  • US 10,105,090 B2
  • Filed: 10/13/2017
  • Issued: 10/23/2018
  • Est. Priority Date: 10/13/2016
  • Status: Active Grant
First Claim
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1. A non-invasive method of detecting breast cancer in a patient via time series measures of the hemoglobin signal, acquired under conditions of a substantially resting state, from at least one breast by comparing the values of coefficients obtained from a functional finite-state transition network representation of said signal, comprising the steps of:

  • non-invasively measuring at least two measured hemoglobin signal components of hemoglobin levels in at least one breast of the patient in a substantially resting state over time, the at least two measured hemoglobin signal components comprising oxygenated hemoglobin and deoxygenated hemoglobin;

    transforming the measured hemoglobin signal components to yield relative changes in the levels of oxygenated and deoxygenated forms of hemoglobin and to compute at least three derived hemoglobin signal components;

    specifying a multiaxis representation of the two measured hemoglobin signal components and the three derived hemoglobin signal components and determining the algebraic sign of each hemoglobin signal component based on their measured relative amplitudes;

    defining the composite of these algebraic sign assignments as a hemoglobin state, of which ten such composites are uniquely defined;

    determining when in time at least one hemoglobin signal component undergoes a change in its algebraic sign and identifying such occurrence as a State transition;

    computing coefficient values for at least one of i) State transition rates, ii) State transition probabilities from the tabulation of unique transition types, or iii) State-dependent component flux of a given State; and

    detecting any cancerous tissue in the measured breast from a signature of said State transitions of the measured breast which differs from a signature of State transitions of non-cancerous tissue.

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