×

Oncolytic herpes simplex virus and therapeutic uses thereof

  • US 10,105,404 B2
  • Filed: 04/17/2017
  • Issued: 10/23/2018
  • Est. Priority Date: 09/08/2011
  • Status: Active Grant
First Claim
Patent Images

1. A variant oncolytic herpes simplex virus (HSV) comprising functionally inactive ICP34.5 encoding genes, wherein at least one of the ICP34.5 encoding genes is rendered functionally inactive by the insertion of an expression cassette comprising:

  • (a) a US11 encoding polynucleotide operably associated with an immediate early (IE) promoter;

    (b) a virus-derived heterologous transporter associated with antigen presentation (TAP) inhibitor encoding polynucleotide; and

    (c) a Interleukin-12 (IL-12) encoding polynucleotide.

View all claims
  • 2 Assignments
Timeline View
Assignment View
    ×
    ×