Multimodal particles, methods and uses thereof
First Claim
1. A composition comprising at least one particle comprised of:
- a nanoscale metal or metal alloy substrate;
a first condensation layer that extends a distance from the nanoscale metal or metal alloy substrate, wherein the distance is up to 10 nm, and wherein the first condensation layer comprises a first dopant entity that is or comprises a SE(R)RS-active agent; and
a second condensation layer comprising a second dopant entity, wherein the second dopant entity is a detectable entity selected from the group consisting of fluorochromes, MM agents, photoacoustic-active dyes, upconverting materials, positron emission tomography (PET) tracers, single photon emission tomography (SPECT) tracers, computed tomography (CT) agents, X-ray agents, ultrasound (US) agents, and combinations thereof so that the first dopant entity and the second dopant entity are detectable by different imaging modalities.
4 Assignments
0 Petitions
Accused Products
Abstract
The present disclosure, among other things, provides a composition of a particle including a substrate; at least a first condensation layer comprising at least a first dopant entity; and at least a second layer comprising a second dopant entity. In some embodiments, different dopant entities are included in different layers. In some embodiments, such dopant entities are or comprise detectable entities. This, in some embodiments, provided technologies achieve multi-modality particles. Among the many advantages of provided technologies include the ability to image particles by a plurality of distinct imaging modalities and/or in a plurality of contexts (e.g., pre-surgical, intraoperative and/or post-surgical environments). The present invention provides methods that include a single administration of particles to a subject, followed by a plurality of steps that comprise imaging the administered particles, which steps may utilize different imaging technologies and/or be performed at different times and/or in different environments.
132 Citations
29 Claims
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1. A composition comprising at least one particle comprised of:
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a nanoscale metal or metal alloy substrate; a first condensation layer that extends a distance from the nanoscale metal or metal alloy substrate, wherein the distance is up to 10 nm, and wherein the first condensation layer comprises a first dopant entity that is or comprises a SE(R)RS-active agent; and a second condensation layer comprising a second dopant entity, wherein the second dopant entity is a detectable entity selected from the group consisting of fluorochromes, MM agents, photoacoustic-active dyes, upconverting materials, positron emission tomography (PET) tracers, single photon emission tomography (SPECT) tracers, computed tomography (CT) agents, X-ray agents, ultrasound (US) agents, and combinations thereof so that the first dopant entity and the second dopant entity are detectable by different imaging modalities. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of preparing a particle, comprising:
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combining a first precursor solution of a first condensation layer in water and alcohol with a first dopant entity; combining the first precursor solution with a nanoscale metal or metal alloy substrate under conditions and for a time necessary and sufficient to apply onto the nanoscale metal or metal alloy substrate the first condensation layer, which first condensation layer extends a distance from the nanoscale metal or metal alloy substrate which is up to 10 nm, resulting in a particle; combining a second precursor solution of a second condensation layer in water and alcohol with a second dopant entity; combining the second precursor solution with the particle under conditions and for a time necessary and sufficient to apply onto the particle the second condensation layer, which second condensation layer has a second predetermined thickness; wherein the first dopant entity is or comprises a SE(R)RS-active agent, and wherein the second dopant entity is a detectable entity selected from the group consisting of fluorochromes, MRI agents, photoacoustic-active dyes, upconverting materials, positron emission tomography (PET) tracers, single photon emission tomography (SPECT) tracers, computed tomography (CT) agents, X-ray agents, ultrasound (US) agents, and combinations thereof so that the first dopant entity and the second dopant entity are detectable by different imaging modalities. - View Dependent Claims (20)
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21. A method comprising a step of providing to a site of interest a collection of particles each comprised of:
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a nanoscale metal or metal alloy substrate; a first condensation layer that extends a distance from the nanoscale metal or metal alloy substrate, wherein the distance is up to 10 nm, and wherein the first condensation layer comprises a first dopant entity that is or comprises a SE(R)RS-active agent; and a second condensation layer comprising a second dopant entity, wherein the second dopant entity is a detectable entity selected from the group consisting of fluorochromes, MRI agents, photoacoustic-active dyes, upconverting materials, positron emission tomography (PET) tracers, single photon emission tomography (SPECT) tracers, computed tomography (CT) agents, X-ray agents, ultrasound (US) agents, and combinations thereof so that the first dopant entity and the second dopant entity are detectable by different imaging modalities. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29)
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Specification