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Antibodies that bind to MHC class I polypeptide-related sequence A

  • US 10,106,611 B2
  • Filed: 12/05/2014
  • Issued: 10/23/2018
  • Est. Priority Date: 12/06/2013
  • Status: Active Grant
First Claim
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1. An antibody or antibody fragment that immunospecifically binds to MEW class I polypeptide-related sequence A (MICA), wherein the antibody or antibody fragment comprises(i) a heavy chain variable (VH) region comprising VH CDR1, VH CDR2, and VH CDR3 as shown in the VH of sequence of SEQ ID NO:

  • 168;

    (ii) a light chain variable (VL) region comprising VL CDR1, VL CDR2, and VL CDR3 as shown in the VL of sequence of SEQ ID NO;

    170; and

    (iii) a heterologous constant region or a heterologous Fc region.

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