Optical coherence photoacoustic microscopy
First Claim
1. A method of optical coherence photoacoustic multi-modal microscopic imaging of a target, the method comprising:
- generating, substantially simultaneously using a light source, A-scans for optical coherence tomography and photoacoustic microscopy of the target;
forming, using a processor, B-scan images for optical coherence tomography and photoacoustic microscopy of the target co-registered in a lateral direction and both formed from photons generated from the A-scans; and
generating, using the processor, a fused image of the target from B-scan image data for optical coherence tomography and photoacoustic microscopy, wherein the photoacoustic microscopy B-scan image data is scaled and interpolated to be co-registered with the B-scan image for optical coherence tomography in a depth direction and to fuse with the optical coherence tomography B-scan data to form a combined optical coherence tomography and photoacoustic microscopy image.
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Accused Products
Abstract
A system and method for providing an optical coherence photoacoustic (OC-PAM) microscopy. An OC-PAM microscope includes a light source that outputs light, a scanner, a detector, a transducer, and an image processing module. The scanner receives the light and scans the light across a sample. The detector receives reflected light from the sample in response to the scanned light. The transducer detects photoacoustic waves induced in the sample by the scanned light. The image processing module receives output from the detector and the transducer and generates a photoacoustic microscopy (PAM) image and an optical coherence tomography (OCT) image based on the received output from the detector and the transducer. The PAM and OCT image data may be fused to form a single, OC-PAM image. Additionally, a series of PAM images and OCT images, respectively, may be combined to generate three-dimensional PAM and OCT images, respectively.
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Citations
16 Claims
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1. A method of optical coherence photoacoustic multi-modal microscopic imaging of a target, the method comprising:
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generating, substantially simultaneously using a light source, A-scans for optical coherence tomography and photoacoustic microscopy of the target; forming, using a processor, B-scan images for optical coherence tomography and photoacoustic microscopy of the target co-registered in a lateral direction and both formed from photons generated from the A-scans; and generating, using the processor, a fused image of the target from B-scan image data for optical coherence tomography and photoacoustic microscopy, wherein the photoacoustic microscopy B-scan image data is scaled and interpolated to be co-registered with the B-scan image for optical coherence tomography in a depth direction and to fuse with the optical coherence tomography B-scan data to form a combined optical coherence tomography and photoacoustic microscopy image. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. An optical coherence photoacoustic microscopy controller apparatus comprising:
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a memory storing instructions for execution; and a computing device configured to execute the instructions stored in the memory to least; generate, substantially simultaneously using a light source, A-scans for optical coherence tomography and photoacoustic microscopy of a target; form B-scan images for optical coherence tomography and photoacoustic microscopy of the target co-registered in a lateral direction and both formed from photons generated from the A scans; and generate a fused image of the target from B-scan image data for optical coherence tomography and photoacoustic microscopy, wherein the photoacoustic microscopy B-scan image data is scaled and interpolated to be co-registered with the B-scan image for optical coherence tomography in a depth direction and to fuse with the optical coherence tomography B-scan data to form a combined optical coherence tomography and photoacoustic microscopy image. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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Specification