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Scanning system and method for imaging and sequencing

  • US 10,107,758 B2
  • Filed: 07/03/2014
  • Issued: 10/23/2018
  • Est. Priority Date: 04/04/2008
  • Status: Active Grant
First Claim
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1. A system for detecting emissions from a plurality of fixed locations on a substrate, the system comprising:

  • a first irradiation source configured to irradiate the substrate and disposed for irradiating a first group of fixed locations of the plurality of fixed locations, wherein the first irradiation source comprises at least one laser source and a holographic beam shaper;

    a second irradiation source configured to irradiate a second group of fixed locations of the plurality of fixed locations, the second irradiation source being fixed with respect to the first irradiation source such that the second group of fixed locations is spaced from and excludes the first group of fixed locations on the substrate;

    a scanning detector array positioned with respect to the first irradiation source and the second irradiation source so as to collect emission from the first group of fixed locations without collecting emission from the second group of fixed locations;

    modulating optics disposed between the first irradiation source and the scanning detector array, wherein the modulating optics comprise a set of prisms including a first prism, a second prism, and a trombone prism configured to operate in conjunction to render intensity consistent across the fixed locations irradiated by the first irradiation source; and

    a translation stage configured to move the first irradiation source, the second irradiation source, and the scanning detector array, together.

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