Volumetric-molecular-imaging system and method therefor

• US 10,107,768 B2
• Filed: 08/13/2014
• Issued: 10/23/2018
• Est. Priority Date: 08/13/2013
• Status: Active Grant

• Current Assignee: Duke University
• Original Assignee: Duke University
• Inventors: Brady, David Jones, Greenberg, Joel Alter, Pang, Shuo, MacCabe, Kenneth Patrick
• Primary Examiner(s): Wong, Don
• Application Number:
  US14/912,014
• Publication Number:
  US 20160187269A1
• Time in Patent Office: 1,532 Days
• CPC Class Codes: G01N 23/20008 Constructional details of analysers, e.g. characterised by X-ray source, detector or optical system; Accessories therefor; Preparing specimens therefor monochromators for X- rays using crystals G21K1/06
• CPC Class Codes: G01N 23/207 Diffractometry using detectors, e.g. using a probe in a central position and one or more displaceable detectors in circumferential positions

Abstract

An imaging system operative for providing a volumetric molecular image of an object is disclosed. The imaging system interrogates the object with structured x-ray radiation while continuous relative motion between the object and source is induced during a measurement period. As the radiation passes through the object, the radiation scatters based on the molecular composition within the object, and the scattering changes as a function of time due to the relative motion between the source and object. Coherent scatter radiation is detected and processed to reconstruct an estimate of the three-dimensional molecular structure of the object using a reconstruction algorithm, such as maximum likelihood estimation.

Claims

1. An imaging system operative for estimating the molecular structure of an object, the imaging system comprising:

a first source that is configured to provide a first radiation beam;

a first coded aperture, the first coded aperture being configured to modulate the first radiation beam to provide a first plurality of beam elements;

a means for changing the interaction between the first plurality of beam elements and the object in a time-dependent manner; and

a detector that is configured to receive radiation based on each of the plurality of beam elements, the detector including a first detector element that is an energy-sensitive detector element, the first detector element being arranged to receive scatter radiation from the object, wherein the detector provides an output signal that is based on the received radiation, and wherein the output signal is a temporally resolved signal.

2. The imaging system of claim 1 wherein the means for changing the interaction between the first plurality of beam elements and the object comprises a stage for moving at least one of the source and the object.

3. The imaging system of claim 1 further comprising a processor, the processor being configured to receive the output signal and compute an estimate of the molecular structure of the object, wherein the estimate is based on a reconstruction that is based on a forward model of the imaging system, and wherein the forward model accounts for both radiation scatter and radiation attenuation by the object.

4. The imaging system of claim 1 further comprising a second coded aperture, wherein the first coded aperture is located between the first source and the object and the second coded aperture is located between the object and the detector.

5. The imaging system of claim 4 further comprising a third coded aperture that is located between the second coded aperture and the detector.

6. The imaging system of claim 1, wherein the first coded aperture includes a code that is controllable.

7. The imaging system of claim 1, wherein the detector further includes a second detector element that is an energy-integrating detector element, the second detector element being arranged to receive non-scattered radiation from the object during the first time period.

8. The imaging system of claim 1 wherein the first source comprises a second source and a third source that are configured to collectively provide the first radiation beam.

9. The imaging system of claim 1, wherein the detector comprises a first plurality of detector elements, each of which is an energy-sensitive detector element, the first plurality of detector elements including the first detector element.

10. The imaging system of claim 9, wherein the first plurality of detector elements is arranged in a linear array that is aligned along a first direction.

11. The imaging system of claim 10, wherein the stage is operative for inducing the relative motion such that it is a linear motion aligned along a first direction.

12. The imaging system of claim 10, wherein the stage is operative for inducing the relative motion such that it is a linear motion aligned along a second direction that is orthogonal to the first direction.

13. The imaging system of claim 9, wherein the first plurality of detector elements is arranged in two-dimensional arrangement.

14. The imaging system of claim 13, wherein the two-dimensional arrangement includes two broken, non-overlapping linear arrays of detector elements.

15. The imaging system of claim 13, wherein the two-dimensional arrangement is non-periodic in each dimension.

16. The imaging system of claim 1, wherein the first coded aperture is configured to spatially modulate the first radiation beam in two dimensions.

17. The imaging system of claim 16, wherein the first coded aperture includes an arrangement of features arranged in a two-dimensional arrangement, the arrangement being aperiodic in at least one of the two dimensions.

18. The imaging system of claim 16, wherein the first coded aperture includes an arrangement of features arranged in a two-dimensional arrangement, the arrangement being aperiodic in each of the two dimensions.

19. The imaging system of claim 1, wherein the first source is configured to provide the first radiation beam as polychromatic radiation.