Volumetric-molecular-imaging system and method therefor
First Claim
1. An imaging system operative for estimating the molecular structure of an object, the imaging system comprising:
- a first source that is configured to provide a first radiation beam;
a first coded aperture, the first coded aperture being configured to modulate the first radiation beam to provide a first plurality of beam elements;
a means for changing the interaction between the first plurality of beam elements and the object in a time-dependent manner; and
a detector that is configured to receive radiation based on each of the plurality of beam elements, the detector including a first detector element that is an energy-sensitive detector element, the first detector element being arranged to receive scatter radiation from the object, wherein the detector provides an output signal that is based on the received radiation, and wherein the output signal is a temporally resolved signal.
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Abstract
An imaging system operative for providing a volumetric molecular image of an object is disclosed. The imaging system interrogates the object with structured x-ray radiation while continuous relative motion between the object and source is induced during a measurement period. As the radiation passes through the object, the radiation scatters based on the molecular composition within the object, and the scattering changes as a function of time due to the relative motion between the source and object. Coherent scatter radiation is detected and processed to reconstruct an estimate of the three-dimensional molecular structure of the object using a reconstruction algorithm, such as maximum likelihood estimation.
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Citations
19 Claims
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1. An imaging system operative for estimating the molecular structure of an object, the imaging system comprising:
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a first source that is configured to provide a first radiation beam; a first coded aperture, the first coded aperture being configured to modulate the first radiation beam to provide a first plurality of beam elements; a means for changing the interaction between the first plurality of beam elements and the object in a time-dependent manner; and a detector that is configured to receive radiation based on each of the plurality of beam elements, the detector including a first detector element that is an energy-sensitive detector element, the first detector element being arranged to receive scatter radiation from the object, wherein the detector provides an output signal that is based on the received radiation, and wherein the output signal is a temporally resolved signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification