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Diagnostic methods for neural disorders

  • US 10,107,796 B2
  • Filed: 01/04/2017
  • Issued: 10/23/2018
  • Est. Priority Date: 04/22/2014
  • Status: Active Grant
First Claim
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1. A method of characterizing a neurological condition, the method comprising:

  • obtaining a human-derived cell having a mutation associated with a condition;

    expressing an exogenous optical reporter and an exogenous optical voltage actuator in the cell;

    illuminating the optical voltage actuator expressed by the cell or a neighboring cell, wherein the optical voltage actuator initiates an action potential in response to the illumination as an optical stimulation;

    detecting an optical signature generated by the optical reporter in response to the optical stimulation of the cell; and

    comparing the detected signature to an expected signature detected from control cell, wherein a difference between the observed signature and the expected signature provides information about the condition.

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