Heterocyclic compounds for the treatment of neurological and psychological disorders

• US 10,112,903 B2
• Filed: 01/19/2018
• Issued: 10/30/2018
• Est. Priority Date: 06/25/2009
• Status: Active Grant

• Current Assignee: Alkermes Pharma Ireland Limited (Alkermes plc)
• Original Assignee: Alkermes Pharma Ireland Limited (Alkermes plc)
• Inventors: Remenar, Julius F., Blumberg, Laura Cook, Zeidan, Tarek A.
• Primary Examiner(s): Pagano, Alexander R
• Application Number:
  US15/875,478
• Publication Number:
  US 20180162816A1
• Time in Patent Office: 284 Days
• CPC Class Codes: A61K 31/496 Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• CPC Class Codes: A61K 31/497 containing further heterocyclic rings
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives
• CPC Class Codes: A61P 25/22 Anxiolytics
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 215/22 attached in position 2 or 4
• CPC Class Codes: C07D 215/227 only one oxygen atom which is attached in position 2
• CPC Class Codes: C07D 241/04 having no double bonds between ring members or between ring members and non-ring members
• CPC Class Codes: C07D 263/58 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
• CPC Class Codes: C07D 401/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 401/14 containing three or more hetero rings
• CPC Class Codes: C07D 413/10 linked by a carbon chain containing aromatic rings
• CPC Class Codes: C07D 413/14 containing three or more hetero rings
• CPC Class Codes: C07D 417/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 417/14 containing three or more hetero rings
• CPC Class Codes: C07D 471/04 : Ortho-condensed systems
• CPC Class Codes: C07F 9/6558 : containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
• CPC Class Codes: C07F 9/65583 : each of the hetero rings containing nitrogen as ring hetero atom

Abstract

Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety disorder and insomnia is disclosed.

Claims

1. A compound having the formula:

3. A pharmaceutical composition comprising the compound of claim 1, and one or more pharmaceutically acceptable carriers or excipients.

5. A method of treating schizophrenia comprising administering the compound of claim 1 to a patient in need thereof.

6. A method of treating bipolar disorder comprising administering the compound of claim 1 to a patient in need thereof.

7. A method of treating depression comprising administering the compound of claim 1 to a patient in need thereof.

8. A method of treating mania comprising administering the compound of claim 1 to a patient in need thereof.

9. A method of treating anxiety comprising administering the compound of claim 1 to a patient in need thereof.

15. A method of treating schizophrenia comprising administering the pharmaceutical composition of claim 3 to a patient in need thereof.

16. A method of treating bipolar disorder comprising administering the pharmaceutical composition of claim 3 to a patient in need thereof.

17. A method of treating depression comprising administering the pharmaceutical composition of claim 3 to a patient in need thereof.

18. A method of treating mania comprising administering the pharmaceutical composition of claim 3 to a patient in need thereof.

19. A method of treating anxiety comprising administering the pharmaceutical composition of claim 3 to a patient in need thereof.

2. A compound having the formula:

4. A pharmaceutical composition comprising the compound of claim 2, and one or more pharmaceutically acceptable carriers or excipients.

12. A method of treating depression comprising administering the compound of claim 2 to a patient in need thereof.

13. A method of treating mania comprising administering the compound of claim 2 to a patient in need thereof.

14. A method of treating anxiety comprising administering the compound of claim 2 to a patient in need thereof.

20. A method of treating schizophrenia comprising administering the pharmaceutical composition of claim 4 to a patient in need thereof.

21. A method of treating bipolar disorder comprising administering the pharmaceutical composition of claim 4 to a patient in need thereof.

22. A method of treating depression comprising administering the pharmaceutical composition of claim 4 to a patient in need thereof.

23. A method of treating mania comprising administering the pharmaceutical composition of claim 4 to a patient in need thereof.

24. A method of treating anxiety comprising administering the pharmaceutical composition of claim 4 to a patient in need thereof.

10. A method of treating schizophrenia comprising administering a compound having the formula:

11. A method of treating bipolar disorder comprising administering a compound having the formula: