MAPC treatment of brain injuries and diseases
First Claim
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1. A method of ameliorating a brain injury caused by hypoxia in a human subject, comprising:
- administering to a human subject having a brain injury caused by hypoxia mammalian multipotent adult progenitor cells characterized in that;
they are not embryonic stem cells, embryonic germ cells, or germ cells, can differentiate into cells of the endodermal, ectodermal, and mesodermal embryonic lineages, are allogeneic to the subject, express telomerase, and are positive for oct3/4, wherein the subject has an immune system and wherein further the subject is not treated with immunosuppressive therapy adjunctively to administration of said cells.
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Abstract
The invention relates to the treatment of various injuries, disorders, dysfunctions, diseases, and the like of the brain with MAPCs, particularly in some aspects, to the treatment of the same resulting from hypoxia, including that caused by systemic hypoxia and that caused by insufficient blood supply. In some further particulars the invention relates, for example, to the treatment of hypoxic ischemic brain injury with MAPCs, in children for example, and to the treatment of cortical infarcts and stroke with MAPCs in adults, for example.
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Citations
19 Claims
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1. A method of ameliorating a brain injury caused by hypoxia in a human subject, comprising:
- administering to a human subject having a brain injury caused by hypoxia mammalian multipotent adult progenitor cells characterized in that;
they are not embryonic stem cells, embryonic germ cells, or germ cells, can differentiate into cells of the endodermal, ectodermal, and mesodermal embryonic lineages, are allogeneic to the subject, express telomerase, and are positive for oct3/4, wherein the subject has an immune system and wherein further the subject is not treated with immunosuppressive therapy adjunctively to administration of said cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
- administering to a human subject having a brain injury caused by hypoxia mammalian multipotent adult progenitor cells characterized in that;
Specification